Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE We report the preliminary results from a phase II study of CT with pegylated interferon-α2 and ruxolitinib in 50 MPN patients (PV, n = 32; low-/intermediate-1-risk MF, n = 18), the majority (n = 47) being resistant and/or intolerant to interferon-α2 monotherapy. 29932310

2018

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b. 25545244

2015

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE Compared with hydroxyurea, interferon alpha 2 b could reduce JAK2V617F load for patients with PV and ET, and achieve higher molecular remission, improve treatment efficacy and reduce complications. 24641389

2014

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE Interferon α-2b gains high sustained response therapy for advanced essential thrombocythemia and polycythemia vera with JAK2V617F positive mutation. 25069759

2014

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells. 22872685

2012

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 GeneticVariation BEFREE We report here the first profound and sustained molecular responses with a JAK2 V617F allele burden below 1.0% in two patients with polycythemia vera treated with interferon alpha-2b (IFN-2b). 18481066

2008

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: feasibility, clinical and biologic effects, and impact on quality of life. 16639737

2006

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE Limited effects on JAK2 mutational status after pegylated interferon alpha-2b therapy in polycythemia vera and essential thrombocythemia. 16956836

2006

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.390 Biomarker BEFREE Possible selective effects of interferon alpha-2b on a malignant clone in a case of polycythemia vera. 8471662

1993