Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE Within this context, elevated CD177 expression is not only a specific feature of PV but may be an indicator of increased erythropoietic activity in thalassaemia syndromes. 18324972

2008

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE In polycythemia vera (PV) and essential thrombocythemia (ET) specific JAK2 mutations constitutively activate the JAK-STAT pathway, explaining biologic findings such as endogenous erythroid colony (EECs) growth or PRV-1 RNA overexpression. 18623127

2008

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Furthermore, overexpression of the PRV-1 gene in PV and ET is associated with a decrease in methylation of this gene. 17976520

2007

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F. 17256145

2007

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE These preliminary observations indicate that the Jak2(V617F) mutation in particular and PRV-1 overexpression appear to be suitable markers for monitoring treatment efficiency in prospective randomised clinical studies comparing pegylated interferon and hydroxyurea in well defined PV patients with a clear indication for cytoreductive therapy. 17852451

2007

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Levels of the mutation were significantly higher in polycythemia vera compared with essential thrombocythemia (P=0.0005) and correlated with the following jointly significant variables at diagnosis: PRV-1, hemoglobin, white cell count, neutrophil count, and red cell count, using multiple regression analyses (P=0.015). 17384217

2007

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE PRV-1 mRNA is overexpressed by neutrophils from polycythemia vera patients and is homologous to NB1 a gene overexpressed in reactive neutrophilia. 16533288

2006

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE However, compared with the PRV-1 assay, mutation screening for JAK2(V617F) displayed greater accuracy in distinguishing PV from SP. 16197445

2005

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE However, quantifying neutrophil PRV-1 mRNA, while complementary to other tests, is not in itself sufficient for the diagnosis of PV. 14701686

2004

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Here, we show that 40% of the PRV-1-positive patients develop symptoms of PV during the course of their disease. 15034760

2004

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE The effects of hydroxyurea on PRV-1 expression in patients with essential thrombocythemia and polycythemia vera. 15477215

2004

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE Instability of PRV-1 mRNA: a factor to be considered in PRV-1 quantification for the diagnosis of polycythemia vera. 15194544

2004

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE We studied neutrophil CD177 mRNA levels in normal subjects and in 235 patients with Ph-negative chronic myeloproliferative disorders (CMD), including PV, essential thrombocythaemia and myelofibrosis with myeloid metaplasia. 15327515

2004

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE Thus, overexpression of PRV-1 in granulocytes from patients with PV is related to mechanisms that do not involve structural genetic changes. 12591276

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE We concluded that, rather than an upregulation of the PRV-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells. 14617008

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE Because there is no overlap between the PRV-1 expression in PV patients versus healthy controls or SE patients, the assay has a very high sensitivity and specificity for the diagnosis of PV in our population. 12893745

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE EECs were observed in 14 of 14 patients with PV and 4 of 12 with ET, and increased granulocyte PRV-1 mRNA levels were found in 9 of 13 patients with PV and 2 of 12 with ET. 12515724

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE In 58 ET patients, a possible association between polycythaemia rubra vera-1 (PRV-1) overexpression and subnormal plasma EPO was investigated, which was always measured prior to the institution of platelet lowering agents. 12756017

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE We observed concordance between EECs and PRV-1 in MPD patients across all diagnostic subclasses, but our results indicate that EECs remain the most reliable auxiliary test for polycythemia vera (PV). 12730106

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE PRV-1 mRNA overexpression, is known to be present in the vast majority of patients with polycythaemia vera and also in some patients with ET. 14617016

2003

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE The overexpression of PRV-1 seems to be a useful tool for discriminating ET and PV from ST and SE, thus offering an innovative diagnostic approach on the basis of the detection of positive diagnostic criteria instead of exclusion criteria. 12377969

2002

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE We have determined the intron-exon structure of the PRV1 gene and show that the locus is structurally intact in patients with polycythemia vera. 12239154

2002

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE The function of the CD177 is not known, but the CD177 gene is highly homologous to a gene overexpressed in neutrophils from patients with polycythemia rubra vera called PRV-1. 11788931

2002

Entrez Id: 57126
Gene Symbol: CD177
CD177
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 AlteredExpression BEFREE We isolated a novel gene, subsequently named PRV-1, which is highly expressed in granulocytes from patients with PV (n = 19), but not detectable in normal control granulocytes (n = 21). 10753836

2000