Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE In BCR-ABL1-negative myeloproliferative neoplasms, myelofibrosis (MF) is either primary (PMF) or secondary (SMF) to polycythemia vera or essential thrombocythemia. 31340059

2019

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia (ET), and primary myelofibrosis frequently harbor JAK2, MPL, and CALR somatic mutations. 28406068

2017

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE The classical BCR-ABL1-negative myeloproliferative neoplasms (MPN) include primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET). 29134817

2017

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE In 1960, Nowell and Hungerford discovered an invariable association between the Philadelphia chromosome (subsequently shown to harbor the causal BCR-ABL1 mutation) and CML; accordingly, the term MPN is primarily reserved for PV, ET, and PMF, although it includes other related clinicopathologic entities, according to the World Health Organization (WHO) classification system. 26492355

2016

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Myelofibrosis (MF) and polycythemia vera (PV) are BCR-ABL1-negative myeloproliferative neoplasms associated with somatic hematopoietic stem cell mutations leading to over activation of JAK-STAT signaling. 27017614

2016

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE The classical BCR-ABL1-negative myeloproliferative neoplasms (MPN) include essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). 26933174

2016

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE The classic BCR-ABL1-negative myeloproliferative neoplasm is an operational sub-category of MPNs that includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). 27039813

2016

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) constitute the BCR-ABL1-negative myeloproliferative neoplasms and are characterized by mutually exclusive Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) mutations; respective frequencies of these mutations are approximately 95%, 0%, and 0% in PV, 60%, 20%, and 3% in ET, and 60%, 25%, and 7% in PMF. 26182311

2015

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Polycythaemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (MF), are the most common myeloproliferative neoplasms (MPN) in patients without the BCR-ABL1 gene rearrangement. 23986553

2014

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE The discovery of the JAK2V617F mutation followed by the discovery of other genetic abnormalities allowed important progress in the understanding of the pathogenesis and management of myeloproliferative neoplasms (MPN)s. Classical Breakpoint cluster region-Abelson (BCR-ABL)-negative neoplasms include 3 main disorders: essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). 25486952

2014

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm diagnosed de novo or developed from essential thrombocythemia (ET) or polycythemia vera (PV). 22793267

2013

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE In the present study, we used mice with a conditional null mutation in the Stat5a/b gene locus to determine the requirement for STAT5 in MPNs induced by BCR-ABL1 and JAK2(V617F) in retroviral transplantation models of CML and PV. 22234689

2012

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells, which fall into distinct categories based on a number of characteristics including the presence of the BCR-ABL1 gene fusion (chronic myelogenous leukemia) or the JAK2(V617F) mutation (polycythemia vera, primary myelofibrosis, and essential thrombocythemia). 22847163

2012

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE Myeloproliferative neoplasms (MPN) that do not contain the BCR-ABL1 mutation include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). 22035746

2011

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE In a group of 36 Mexican mestizo patients with MPN, we studied five molecular markers: The BCR/ABL1 fusion gene, the JAK2 V617F mutation, the JAK2 exon 12 mutations, the MPL W515L mutation and the MPL W515K mutation; 17 patients with essential thrombocythemia (ET), eight with polycythemia vera (PV), four with primary mielofibrosis (MF), five with undifferentiated MPN, one with primary erythrocytosis and one with familial thrombocytosis. 19843380

2009

Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE We report results of bcr analysis by Southern hybridization in 37 patients with MPDs other than CML: ET (20 cases), PV (seven cases). unclassified MPD (nine cases), as well as in one case of chronic myelomonocytic leukemia (CMML). bcr negativity ruled out CML in 36 cases, confirming the morphologic diagnosis.In one case diagnosed as ET. bcr gene rearrangement was diagnostic of CML. 8818385

1996