Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.040 GeneticVariation BEFREE Here we show that retroviral overexpression of Jak2 V617F mutant into wild-type p53 murine bone marrow cells induced polycythemia vera (PV) in the recipient mice, whereas Jak2 V617F-transduced p53-null mice developed lethal leukemia after the preceding PV phase. 28068330

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.040 Biomarker BEFREE Moreover, inhibition of p53 in PV erythroblasts resulted in more gamma-H2Ax (γ-H2Ax)-marked double-stranded breaks compared with in like-treated ET erythroblasts, suggesting the defective intra-S checkpoint function seen in PV increases DNA damage in the context of attenuated p53 signaling. 25288776

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.040 Biomarker BEFREE These data suggested that disruptions of both genes are extremely rare in MPD in chronic phase and that loss of functions in the p53 gene could be involved in progression of MPD such as PV and ET. 12353315

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.040 PosttranslationalModification BEFREE These data indicate that inactivation of TP53 is a relatively frequent event associated with the blastic transformation of PV and ET and may be responsible for the tumor progression of these disorders. 9258660

1997