Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.560 AlteredExpression BEFREE In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-γ, TNF-α and IL-4 were strongly inhibited (p<0.001, p<0.001 and p<0.0094), compared to PMA treatment alone, for both, rhinitis and asthma. 30537802

2018

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.560 GeneticVariation BEFREE However, we found that the IL4-589*T allele was associated with "probable" asthma (RR = 4.1) and that homozygotes for the IL4-589*T allele had an increased risk for the development of rhinitis (RR = 2.4). 10806171

2000

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.560 AlteredExpression BEFREE It was previously reported that at 24 h after allergen provocation, CD3+ T-lymphocytes were the principal cell source of IL-4 and IL-5 mRNA transcripts in both atopic asthma and rhinitis. 11122208

2000

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.560 AlteredExpression BEFREE Nasal allergen provocation has demonstrated that allergen-induced rhinitis is associated with an increase in local IL-4 mRNA and IgE heavy chain (Cepsilon) and IgE heavy chain promoter (Iepsilon) RNA and that pretreatment with topical glucocorticosteroids inhibits the increase in these transcripts. 9525448

1998

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.560 Biomarker BEFREE Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis. 7927488

1994

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.560 AlteredExpression BEFREE These results demonstrate that recruitment of eosinophils during human allergen-induced rhinitis is associated with cells expressing mRNA for IL-3, IL-4, IL-5, and granulocyte/macrophage-CSF. 1560199

1992