Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Higher IL6 and YKL-40 levels at the time of tumor progression and serum IL6 measured over time were associated with shorter overall survival. 31685562

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The IL-6/STAT3 pathway is a key regulator of genes involved in cancer progression. 31850822

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE IL-6 is a pro-inflammatory cytokine that when dysregulated stimulates inflammatory diseases and tumor progression. 31542660

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines (P < 0.05 O-SED vs. 2-month-old Y-CON), was potently mitigated by lifelong AET (P < 0.05 O-AET vs. O-SED), including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). 30682077

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE A growing body of evidence indicated that glycoprotein 130 kDa (GP130), the pivotal mediator involved in interleukin 6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) signaling pathways, is strongly correlated with tumor progression. 30852762

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our results showed that IL-6 and integrin ανβ6 are indicators of cancer progression and poor prognosis in patients with colon cancer. 30982362

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The combination of DOX and KIR may promote therapeutic efficacy, at which the anti-apoptotic effect of the tumour cells was inhibited (by downregulating Bcl-2 and upregulating Bax) and the tumour progression-related inflammatory factors, such as tumour necrosis factor α (TNF-α) and interleukin-6 (IL-6) were downregulated. 30880468

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Inflammatory markers, such as interleukin-6 (IL-6), have been associated with both the malignant transformation of epithelial cells and tumor progression, thus linking low-grade inflammation with a higher risk of cancer and recurrence in the survival phase. 31414667

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Polyps from LT<sup>het</sup> mice, <i>Stk11</i><sup>+/-</sup> mice, and human PJS patients display hallmarks of chronic inflammation, marked by inflammatory immune-cell infiltration, signal transducer and activator of transcription 3 (STAT3) activation, and increased expression of inflammatory factors associated with cancer progression [interleukin 6 (IL-6), IL-11, and CXCL2]. 30049881

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Cancer progression has appeared to be associated with a progressive decline in the blood levels of the main antitumor cytokines, including IL-2 and IL-12, in association with an increase in those of inflammatory cytokines, including IL-6, TNF-alpha, and IL-1-beta, and immunosuppressive cytokines, namely TGF-beta and IL-10. 29705848

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In sum, therefore, we have identified an lncRNA-based IL-6/STAT3 signaling regulatory circuit that promotes tumorigenesis and metastasis in cervical cancer cells, highlighting the role that lncRNAs can play in tumor progression. 30094092

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Ligand-independent phosphorylation and activation of ER-β may play a relevant role in the IL-6/STAT3 signaling pathway and, as a result, in tumor progression. 30046904

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. 27797936

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Interleukin-6 (IL-6) is closely associated with tumor progression. 29723410

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Incubation of pDCs with single cytokines relevant for cancer progression within the HNSCC micro milieu show that IL-6 or IL-8 have no influence on the IFN-α secretion in pDCs, whereas IL-10 massively impairs the secretion in a dose dependent manner. 29456743

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Finally, we discuss the role of IL-6 in various aspects of cancer progression. 29413760

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Interleukin 6 (IL-6) was abundant in the tumor microenvironment and played potential roles in tumor progression. 28828629

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. 28928376

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Pretreatment serum interferon-γ, and interleukin-6 and -10 levels were significantly higher in the patients with objective tumor responses than in those with tumor progression.In conclusion, giving repeated i.v. nivolumab had potent and durable antitumor effects and a manageable safety profile in advanced melanoma patients, strongly suggesting the usefulness of nivolumab for advanced melanoma and the usefulness of pretreatment serum cytokine profiles as correlates for predicting treatment efficacy. 28266140

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. 28548958

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Here, we hypothesize that endothelial cell-secreted interleukin-6 (IL-6) contributes to tumor progression by enhancing the migratory phenotype and survival of cancer stem cells. 29245982

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Therefore, specific inhibition of IL-6 trans-signaling, rather than total inhibition of IL-6 signaling, is sufficient to blunt tumor initiation and impair tumor progression without compromising IL-6 classic signaling-driven protective immune responses.(Hepatology 2017;65:89-103). 27770462

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The aim of this study was to elucidate whether serum levels of IL-6 and IL-8 at diagnosis could predict the tumor progression pattern of PDAC, especially in extensive hepatic metastasis.According to the tumor burden of hepatic metastasis at the last follow-up, tumor progression pattern was defined as follows: no or limited (unilobar involvement and 5 or less in the within liver, limited group) and extensive hepatic metastasis (bilobar or more than 5, progressed group). 28151872

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE IDO and IL-6 incorporate a positive feedback signal loop to maintain IDO and IL-6 constitutive expression and facilitate tumor progression. 29296206

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Inflammation contributes to tumor progression and can be induced by excessive production of pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α). 28791816

2017