Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE WW domain containing E3 Ub-protein ligase 2 (WWP2) plays an important role in tumor progression as an E3 ligase of PTEN. 31677789

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Interestingly, some data confirmed that loss of PTEN expression modified the pattern of cytokine secretion creating an immune-suppressive microenvironment with increase of immune cell populations that can promote tumor progression. 31500143

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE PTEN is a ubiquitous tumor suppressor that is often decreased in prostate cancer during tumor progression. 31213464

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE In prostate cancer, ITH, a potential factor affecting tumor progression, is associated with PTEN deletion and cytotoxic T cell inactivation. 30265975

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Phosphatase and tensin homolog (PTEN) is a well‑known tumor suppressor and serves a vital role in cancer progression. 30542737

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The impact of PTEN-Δ in context of tumor progression should thus be taken into account when generating new therapeutic options targeting PTEN signaling in RCC. 29954386

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The SH2B1/Akt/mTOR/PTEN axis is required for regulating NSCLC cell proliferation and might prove to be a promising strategy for restraining tumor progression in NSCLC patients. 30202243

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Here, <i>PTENP1</i> 3'UTR transduction influences PTEN, AKT/mTOR signaling, and tumor progression in estrogen receptor (ER)-positive and -negative breast cancer cells. 29021233

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Even a subtle decrease in PTEN levels and activity results in cancer susceptibility and favours tumour progression. 29858604

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The present study demonstrates for the first time that electrophilic 15d-PGJ<sub>2</sub> directly binds to cysteine 136 of PTEN and provides new insight into PTEN loss in cancer progression associated with chronic inflammation. 29550515

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our results suggest miR-1297 may drive tumor progression through PTEN. 30108442

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Taken together, our results elucidate the role of the LINC00312-miR-21-PTEN axis in CRC cell proliferation and tumour progression and may lead to new lncRNA-based diagnostics or therapeutics for CRC. 30134003

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha). 28747658

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Deep genetic studies revealed that <i>phosphatase and tensin homolog</i> (<i>PTEN</i>) mutations or loss of expression are not early events in cancer development but characterize tumor progression and invasion. 28848709

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE TTF-1 and PTEN can be used as molecular markers for the early diagnosis of endometrial cancer, which are closely related to clinical features and may affect tumor progression by regulating the proliferation activity of tumor cells. 28745797

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Both upregulated miR-21 and downregulated PTEN expression have a possible correlation with the aggressive progression and poor prognosis of WT, which suggests that upregulated miR-21 and downregulated PTEN expression may be valuable markers of tumor progression and indicators of the prognosis of WT. 28040201

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Conversely, genetic ablation of Whsc1 prevented tumor progression in PTEN-null mice. 28319045

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. 27993894

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Importantly, we found a PTEN somatic mutation (T401I) that is defective in disrupting the association between SNX27 and VPS26, suggesting a critical role for PTEN in controlling optimal GLUT1 levels at the membrane to prevent tumor progression. 29117568

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Prompted by our observation of a correlation between PTEN loss and FAK phosphorylation in a cohort of patients with stage IV SCC, we evaluated the relevance of PTEN loss in cancer progression as well as the efficacy of a new combined treatment with the pan PI3K inhibitor buparlisip and the FAK inhibitor defactinib. 28881794

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 PosttranslationalModification BEFREE Our data suggest that a low PTEN and p16 expression due to methylation may contribute to the cancer progression and could be useful for prognosis of OSCC. 26687648

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The tumor-specific overexpression of TOB1 results in the activation of other tumor suppressor proteins, such as mothers against decapentaplegic homolog 4 (SMAD4) and phosphatase and tensin homolog-10 (PTEN), and blocks tumor progression. 26694352

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE DGCR8 is essential for tumor progression following PTEN loss in the prostate. 26206718

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Predicted alterations in expression levels of candidate genes in each of the recurrent CNA regions characteristic of each subgroup showed that signaling networks associated with cancer progression and genome stability were likely to be perturbed at the highest level in the PTEN deleted genomic subgroup. 25434580

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE To date, no data have been reported concerning the influence of PTEN/PI3K signaling pathway on EMT in human esophageal squamous cell carcinoma (ESCC) and how TGF-β1 and PTEN/PI3K act through multiple interconnected signaling pathways to trigger events associated with EMT and tumor progression. 25175594

2014