Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Cyclooxygenase-2 (COX-2) plays a crucial role in cancer progression. 31473273

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE While previous studies have shown that the number of circulating tumor cells (CTCs) alone is not sufficient to reflect tumor progression and that cyclooxygenase-2 (COX-2) expression is correlated with colorectal cancer (CRC) metastasis, COX-2 expression status and its potential functions in CTCs of CRC patients are unknown. 30260024

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Cross-talking between MAPK with oncogenic signaling pathways including WNT, cyclooxygenase-2, transforming growth factor-β, NOTCH and (in particular) with phosphatidylinositol 3-kinase is contributed to the multiplication of tumor progression and drug resistance. 31136035

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The cyclooxygenase-2 (COX-2) enzyme has been shown to increase in bladder cancer and has a direct relationship with tumor progression. 31443756

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase-2, COX-2)-prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) pathway promotes tumour progression. 30826660

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE TFAP2B bound to the promoter of COX-2 to activate its expression, indicating that TFAP2B is a critical regulatory molecule in the COX-2 signaling pathway that promoted tumor progression in thyroid cancer. 31113934

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The aim of our study; is to investigate the clinicopathological and the prognostic significance of SCF and COX-2 expression in prostatic adenocarcinoma (PC), chronic prostatitis and nodular prostatic hyperplasia (NPH) in a trial to clarify the role of inflammation as a risk factor for prostatic carcinogenesis and cancer progression. 30402808

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The positivity of p53 and COX-2 in a large proportion of BCCs, regardless of histological type and of depth of invasion, supports the two markers involvement in tumor progression. 30845292

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE It was known that alterations in COX2 gene functions contribute to the inflammation process thus induce cancer progression, including cell proliferation, apoptosis, adhesion, invasion and metastasis. 30511628

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression. 29257333

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Elevated cyclooxygenase-2 (COX-2) closely associates with tumor progression and distant metastasis in various human cancers. 29932878

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The aim herein was to evaluate the Nintedanib therapeutic effects on morphology and COX-2 and IL-17 levels in the prostate anterior lobe in different grades of the tumor progression in TRAMP mice. 29429524

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE It is now recognized that COX-2 over expression promotes tumorigenic functions which can be suppressed by COX-2 inhibitors, a phenomenon useful for the preventing of tumor progression. 28971779

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Consequently, the regenerative stimulus seems to be driven by a pro-inflammatory and hypoxic environment, in which M1 intrahepatic macrophages expressing COX-2 and T-Lymphocytes play a key role, facts which may be related with the tumor progression observed. 29795479

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We also found that the in vivo microenvironment enhanced activation of the COX-2 pathway, which further contributed to cancer progression. 29396430

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Significant correlations were observed with expression levels of key proteins involved in tumor progression and invasion namely E-cadherin and Cyclooxygenase-2. 29340045

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Gene expression analysis by microarray demonstrated that MDR1A deficiency shaped the inflammatory response towards an anti-tumorigenic microenvironment by downregulating genes known to be important mediators of cancer progression (PTGS2 (COX2), EREG, IL-11). 28686677

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE COX-2 is currently investigated as a major player of tumor progression in several type of malignancies including melanoma. 28231855

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Expression of EpCAM and COX‑2 was revealed to be associated with tumor progression, and poor prognosis in breast cancer. 28393249

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE In conclusion, we found a correlation between H-ras expression and Cox-2 induction in OSCC tissue, suggesting that together these genes are contributing to cancer progression. 27628320

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The cyclooxygenase-2 (COX-2) inhibitor did not prevent cancer progression and did not affect the total number of macrophages in the tongues of 4NQO-treated mice. 28633143

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our results point to a role for COX-2 in angiogenesis and in the establishment of an inflammatory microenvironment, favourable to melanoma tumour progression. 27105172

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE MIR21 expression level in colorectal carcinoma is associated with worse clinical outcome, and this association is stronger in carcinomas expressing high-level PTGS2, suggesting complex roles of immunity and inflammation in tumor progression. 26957558

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE COX-2 and its product PGE2 enhance carcinogenesis and tumor progression, which has been previously reported in melanoma. 26801201

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE To understand the role of COX-2 in tumor progression within a collagen-dense microenvironment, we treated MMTV-PyMT or MMTV-PyMT/Col1a1 (tm1jae) tumors prior to and after tumor formation. 27000374

2016