Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.360 Biomarker BEFREE In conclusion, the present findings indicate a role for miR‑296 as a tumor suppressor in pancreatic cancer through directly targeting AKT2, thus suggesting that miR‑296 may serve as a potential therapeutic target for the treatment of pancreatic cancer. 28534950

2017

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.360 Biomarker BEFREE Cyclin D1 (CCND1), v‑akt murine thymoma viral oncogene homolog 2 (AKT2), cyclin‑dependent kinase 6 (CDK6) and SMAD family member 2 (SMAD2) were involved in the pathway of pancreatic cancer. 27840954

2016

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.360 AlteredExpression BEFREE We suggest that AKT2 inhibition abrogates gemcitabine-induced activation of AKT2 and NF-κB, and promotes gemcitabine-induced PUMA upregulation, resulting in chemosensitization of pancreatic tumors to gemcitabine, which is probably an important strategy for the treatment of pancreatic cancer. 22312312

2012

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.360 Biomarker BEFREE Therefore, RNAi simultaneously silencing the oncogenes K-ras and Akt2 may offer potential opportunities for pancreatic cancer gene therapy. 18949011

2009

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.360 Biomarker BEFREE Furthermore, the role played by the AKT2 kinase in the signaling pathways of various mitogenic growth factors implicated in the development of pancreatic cancer suggests that alteration of AKT2 may be an important component in the pathogenesis of a substantial subset of PDACs. 9496907

1998

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.360 GeneticVariation BEFREE Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer. 8780719

1996