Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Genomic studies identified nine mutations in seven genes known to play a potential role in tumorigenesis in T-cell leukaemia/lymphoma, including PLCG1, JAK3 and STAT3, which underlies the activation of these key cell-survival pathways. 31049933

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We identify a critical role of increased oxidation of fatty acids driven by leptin and PD-1 through STAT3 in inhibiting CD8<sup>+</sup> T effector cell glycolysis and in promoting obesity-associated breast tumorigenesis. 31761565

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Further, dual-luciferase reporter assays identified STAT3 as a direct target of miR-590-5p, which negatively regulated STAT3 activation and its downstream signaling molecules (e.g., Cyclin D1, c-Myc, Vimentin, and β-catenin) involved in tumorigenesis. 31520555

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MAPK, Akt, and STAT3 pathways might play diverse roles in oral carcinogenesis. 31062130

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Herein, we discuss current experimental and clinical evidence that highlights the pivotal role of STAT3 in glioma tumorigenesis and particularly in shaping tumor immune microenvironment in an effort to justify the high need of selective targeting for glioma immunotherapy. 31698775

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Microarray gene expression profiling demonstrated that the suppressed gastric tumorigenesis in pS-STAT3-deficient <i>gp130</i><sup>F/F</sup> mice associated with reduced transcriptional activity of STAT3-regulated gene networks implicated in cell proliferation and migration, inflammation, and angiogenesis, but not mitochondrial function or metabolism. 31481496

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Further similarities between ontogenesis and oncogenesis involving crucial factors, such as ID, HSP70, HLA-G, CD44, LIF, and STAT3, are strongly evident at molecular, physiological and immunological levels. 30899759

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The knockdown of SOCS3 increased the expression level of the JAK2 V617F mutant, which enhanced the activation of signaling mediators, including signal transducer and activator of transcription 3 and 5 (STAT3, STAT5) and extracellular signal-regulated kinase (ERK), and also increased of the proliferation rate and tumorigenesis activity of Ba/F3 cells expressing the JAK2 V617F mutant and erythropoietin receptor (EpoR). 31255914

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE LncRNA SNHG16 aggravates tumorigenesis and development of hepatocellular carcinoma by sponging miR-4500 and targeting STAT3. 30779219

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Our results demonstrated the anticancer efficacy of Ova in NPC and its potential as a putative inhibitor of JAK2 and STAT3, which are essential in tumorigenesis of NPC. 30668347

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE In addition, we showed that the effects of HOXA10 on the promotion of cell viability and tumorigenesis and cell apoptosis repression were all weakened when JAK1 or STAT3 was downregulated. 31406476

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE LDOC1 knockdown considerably augmented tumorigenesis and the phosphorylation of JAK2 and STAT3 in vivo. 30634502

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This study highlights that exosomal ZFAS1 promotes the proliferation, migration and invasion of ESCC cells and inhibits their apoptosis by upregulating STAT3 and downregulating miR-124, thereby resulting in the development of tumorigenesis of ESCC. 31775815

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE S1PR1-mediated tumorigenesis is supported and amplified by activation of downstream effectors including STAT3, interleukin-6, and NF-κB networks. 31115798

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. 31061131

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The IL-6/STAT3 pathway has been confirmed to play essential roles in the process of carcinogenesis, including gastric cancer. 30961685

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We were able to elucidate the contribution of miRNAs in the NF-κB - STAT3 crosstalk during the stepwise development of colitis-associated carcinoma, and this could improve our understanding of the molecular pathology of colorectal tumorigenesis and even suggesting a therapeutic strategy by modulating the expression of these regulating miRNAs. 31479716

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Administration of STAT3 inhibitor WP1066 could prevent MVP knockdown induced tumorigenesis. 31092229

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In contrast, intestinal tumorigenesis was not suppressed by Stat3 disruption in adenomatous polyposis coli ( Apc) <sup>Δ716</sup> and Apc<sup>∆716</sup> Tgfbr2<sup>∆IEC</sup> mice, thus indicating that Stat3 is not required for Wnt activation-driven intestinal tumorigenesis. 30156908

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Driven by dysregulated IL-6 family member cytokine signaling in the tumor microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) and (STAT5) activation have been identified as key contributors to tumorigenesis. 31684144

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Despite the role of STAT3 as a known driver of oncogenesis, efforts to develop therapeutic STAT3 inhibitors have thus far been unsuccessful. 31715126

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This review provides a concise overview of the current knowledge on STAT3 during tumorigenesis, with special emphasis on the unique and complex roles of its alternatively spliced isoforms. 30031681

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE Analysis of gastric tissues from the TFF1 knockout (KO) mouse model of gastric neoplasia, demonstrated phosphorylation of STAT3 in the early stages of gastric tumorigenesis. 31235784

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Experimental studies have shown that the IL6/GP130/STAT3 pathway is involved in pancreatic cancer tumorigenesis and progression as well as in the development of other tumors. 31139333

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The overexpression of miR-296-5p by targeting STAT3 suppressed tumorigenesis of ESCC cells. 31298412

2019