Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE MicroRNA-142-3p/MALAT1 inhibits lung cancer progression through repressing β-catenin expression. 30970294

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE In our previous study, succinate dehydrogenase 5 (<i>SDH5</i>) was reported to regulate ZEB1 expression, induce EMT and lead to lung cancer metastasis via the GSK3β/β-catenin pathway. 31741753

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway. 31796785

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE The results indicated that miR-146-5p promoted cell viability, migration and invasion, inhibited apoptosis and activated Wnt/β-catenin and PI3K/AKT/MAPK signal pathways by regulating claudin-12 expression in lung cancer cells. 31006666

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE These results suggest that TRIB3 interacts with β-catenin and thus activates β-catenin signaling, which is responsible for lung cancer progression, and blocking TRIB3 activity might be developed to treat lung cancer. 31562867

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE In addition, oncogenes CTNNB1 and FN1 were highly edited and significantly overexpressed in malignantly transformed cell lines, thus may be responsible for the lung cancer progression. 31158229

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Furthermore, lumichrome potentially suppressed cancer stem cells (CSCs) in lung cancer by dramatically suppressing CSC markers together with the CSC-maintaining cell signaling namely protein kinase B (AKT) and β-catenin. 31074646

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE In addition, β-catenin upregulation enhanced miR-421 expression, indicating that β-catenin regulates the expression of miR-421 in lung cancer. 31659154

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE β-catenin is important in development of lung cancer. 29974605

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/β-catenin Signaling. 28972040

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 GeneticVariation BEFREE These results supports combined EGFR-TKI and β-catenin inhibition in patients with EGFR mutant lung cancer. 30097569

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis. 29496538

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway. 29393404

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE The effect of si-CCAT2 on the expression of nuclear and cytoplasmic β-catenin protein in the lung cancer NCI-H1975 cell line was detected using western blot analysis. 30214594

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Hypoxia Stimulates the Epithelial-to-Mesenchymal Transition in Lung Cancer Cells Through Accumulation of Nuclear β-Catenin. 30396950

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer. 29739711

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 GeneticVariation BEFREE Associations between environmental variants together with single nucleotide polymorphisms (SNPs) of beta-catenin (ctnnb1) and lung cancer risk were analyzed using a logistic regression model. 29562493

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE MORC2 Enhances Tumor Growth by Promoting Angiogenesis and Tumor-Associated Macrophage Recruitment via Wnt/β-Catenin in Lung Cancer. 30504718

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE Knockdown of Wnt3 expression in lung cancer cells inhibited the expression of β-catenin and cyclin D1 genes in Wnt/β-catenin pathway. 29565490

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE These results show that PDE10 is overexpressed during lung cancer development and essential for lung tumor cell growth in which inhibitors can selectively induce apoptosis by increasing intracellular cGMP levels and activating PKG to suppress oncogenic β-catenin and MAPK signaling. 29050202

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 AlteredExpression BEFREE Mechanistically, we affirmed that QKI-5 reduced β-catenin level in LC cells via suppressing its translation and promoting its degradation, whereas QKI-5 promoter hypermethylation suppressed QKI-5 expression. 29137254

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways. 28198062

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE MiR-410 induces stemness by inhibiting Gsk3β but upregulating β-catenin in non-small cells lung cancer. 28076327

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE Finally, western blot assays demonstrated that there was no difference in β‑catenin and glycogen synthase kinase 3β (GSK‑3β) expression in cancer cells compared with NL‑20, but increased phosphorylated (p‑)β‑catenin and p‑GSK‑3β was detected in lung cancer cell lines compared with NL‑20, particularly in A549 cells. 28849055

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.300 Biomarker BEFREE The transcription factor clusters of β-catenin/Snail1/Twist has been implicated in the process of epithelial mesenchymal transition (EMT), an intermediate between smoking and airway fibrosis, and indeed lung cancer. 28883453

2017