Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.350 Biomarker BEFREE However, the detailed function of NTRK2 in lung cancer, especially in lung adenocarcinoma (LUAD), is still not fully understood. 31245181

2019

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.350 Biomarker BEFREE Neurotrophic tyrosine kinase genes encode for the Trk-family proteins TrkA, TrkB, and TrkC, which have an important role in the development of the nervous system; however, they have been identified as oncogenic fusions in solid tumors (NTK-1, NTRK-2, and NTRK-3) and are associated with poor survival in lung cancer. 29085074

2017

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.350 Biomarker BEFREE Recently, several studies have suggested that BDNF and/or its receptor, tropomyosin related kinase B (TrkB), are involved in tumor growth and metastasis in several cancers, including prostate cancer, neuroblastoma, pancreatic ductal carcinoma, hepatocellular carcinoma, and lung cancer. 27456333

2016

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.350 AlteredExpression BEFREE An in vitro system designed to discover factors critical for lung cancer cell migration identified brain-derived neurotrophic factor, which stimulates cell migration through activation of tropomyosin-related kinase B (TrkB; also called NTRK2). 24982195

2014

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.350 AlteredExpression BEFREE The expressions of TrkB and BDNF analyzed by immunohistochemistry for patients samples with lung cancer (n=104) were significantly higher in neuroendocrine tumor (NET) compared with non-NET. 23312550

2013