Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 Biomarker BEFREE In vitro and in vivo experiments revealed that tumor-derived G-CSF and G-CSF-mediated IL-6 production from the tumor microenvironment are involved in the development of leukocytosis and thrombocytosis in patients with endometrial cancer. 31741758

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 Biomarker BEFREE IL-6 acts on hepatocytes to enhance the production of thrombopoietin, which in turn interacts with its cognate receptor c-MPL on megakaryocytes and bone marrow progenitor cells to promote their expansion and proliferation, resulting in reticulated thrombocytosis. 28504650

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 AlteredExpression BEFREE Serum IL-6 level was frequently elevated in patients with SSc, particularly in those with diffuse cutaneous SSc (dcSSc) with thrombocytosis and elevated acute phase markers. 22586157

2012

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 AlteredExpression BEFREE We present here the first case in the literature with MDS/MPD syndrome, sole 5q- anomaly and thrombocytosis in which bortezomib administration normalized platelet count, produced a major erythroid response, and reduced levels of interleukin-6 (IL-6) and TNF-alpha while increased levels of IL-4 in the bone marrow plasma. 16820206

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 Biomarker BEFREE It is shown that IL-6-induced thrombocytosis in C57BL/10 mice is accompanied by enhanced hepatic TPO mRNA expression and elevated TPO plasma levels. 11675343

2001

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 Biomarker BEFREE Thus, IL-6 could cause thrombocytosis in inflammatory disease partly by increasing hepatic TPO production. 10841078

2000

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 AlteredExpression BEFREE Since it is possible that TPO participates in thrombocytosis and the tumor growth of this particular hepatic tumor, serum TPO levels in addition to interleukin 1beta (IL-1beta) and IL-6 levels were assessed in seven untreated patients by using a sandwich enzyme-linked immunosorbent assay. 9766812

1998

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 Biomarker BEFREE A role for interleukin-6 (IL-6) in malignant mesothelioma has been suggested by the clinically presenting symptoms of mesothelioma patients, which include fever, weight loss and thrombocytosis. 7750122

1995