×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Boosting the apoptotic response of high-grade serous ovarian cancers with CCNE1 amplification to paclitaxel in vitro by targeting APC/C and the pro-survival protein MCL-1.
31286496 2020
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
From TCGA database, we found that polyamine metabolism was significantly enriched in Cyclin E1 -driven OvCa .
31657115 2019
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
31060523 2019
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
AlteredExpression
BEFREE
Our finding indicates that miR-107 serves as a tumor suppressor by decreasing CCNE1 expression levels, which may provide potential therapeutic strategies in ovarian cancer treatment.
30885433 2019
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
AlteredExpression
BEFREE
19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes.
30209015 2018
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Recently, amplification of CCNE1 was found to be another major factor in HGSOC tumorigenesis, accounting for approximately 20% of all cases.
27898521 2017
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Selective Targeting of Cyclin E1 -Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.
27663592 2017
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
AlteredExpression
BEFREE
Histo-genomic stratification reveals the frequent amplification/overexpression of CCNE1 and BRD4 genes in non-BRCAness high grade ovarian carcinoma .
25892415 2015
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Prompted by recent genomic analyses that identified cyclin E1 (CCNE1 ) gene amplification as a candidate oncogenic driver in high-grade serous ovarian carcinoma , we evaluated the functional role of cyclin E1 in serous carcinogenesis.
24366882 2014
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women.
23787073 2013
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1 -amplified ovarian cancer .
24004674 2013
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
These observations have implications for the application of targeted therapies in CCNE1 dependent ovarian cancers .
21103391 2010
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
CCNE1 gene knockdown using silencing RNA and a CCNE1 gene transfection system were used to asses CCNE1 function in tissue samples of ovarian cancer .20336784 2010
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
Biomarker
BEFREE
CCNE1 copy number is validated as a dominant marker of patient outcome in ovarian cancer .19193619 2009
×
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
Malignant neoplasm of ovary
0.600
GeneticVariation
BEFREE
A nominally statistically significant association between genotype and ovarian cancer survival was observed for polymorphisms in CCND2 and CCNE1 .
18281541 2008