Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE The effects of miR‑21 on the invasion, migration and angiogenesis of RCC cells was determined through meta‑analysis and regulation of miR‑21 expression in vitro. 31789394

2020

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Besides, the relation between PTEN and miR-21 was detected by luciferase assay. circC3P1 and PTEN were downregulated while miR-21 was upregulated in KC tissues. circC3P1 declined cell viability, migration, and invasion and caused apoptosis. 31643094

2020

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE The effects of miR‑21 on bladder cancer cell migration and invasion were analysed by Transwell and Matrigel assays following miR‑21 transfection. 31814034

2020

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Overexpression of miRNA-21 Promotes the Proliferation and Invasion in Hepatocellular Carcinoma Cells via Suppressing SMAD7. 31554487

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE High expression of miR-21 and low expression of miR-145 are closely related to the development and progression of CRC, especially with the grade of differentiation, invasion, metastasis and clinical stage. 29552756

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE LINC-PINT overexpression led to inhibited, while miR-21 overexpression led to promoted proliferation, migration, and invasion of gastric cancer cells. 30569513

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Compared with the control group, DLN (5 µl) or miR‑21 inhibitor significantly reduced migration and invasion of melanoma cells, promoted apoptosis and arrested cells at the G1 phase. 31115580

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE In conclusion, lncRNA PLAC2 down-regulated miR-21 in NSCLC and inhibited cancer cell migration and invasion. 31500623

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Knockdown miR-21 increased the expression of VHL, and thus modulated the HIF-1α/VEGF pathway and the expression of MMP-2 and MMP-9, which led to the inhibition of the proliferation, migration and invasion of pancreatic cancer cells. 31564905

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE In ovarian cancer tissues and cells, miR‑21 was highly expressed, and the high expression of miR‑21 could activate the Wnt signaling pathway to regulate the expression of CD44v6 and affect the proliferation, invasion and migration of OC cells. miR‑21 regulated the expression of CD44v6 by activating the Wnt signaling pathway, which plays an important role in the development of ovarian cancer. 31115569

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE In addition, miRNA-21 overexpression partially rescued the inhibited cell proliferation, migration, and invasion mediated by LncRNA LINC-PINT overexpression. 31070482

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Moreover, the expression levels of miR-182, miR-183, miR-141, and miR-21 were demonstrated to be associated with a gradual increase in fold change expression with depth of tumor invasion (all P < .05), lymph node invasion (all P < .001), and maximal increase with distant metastasis (all P < .001). 31764853

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE The results therefore show that, HCC cell migration and invasion is significantly suppressed by miR-21 via targeting KLF5. 30675287

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Our data showed that miR-21 overexpression significantly increased cell invasion and decreased apoptosis in FLSs. 30599075

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Plasma levels of lncRNA HAND2-AS1 were lower in ESCC patients than in healthy controls, and downregulation of plasma lncRNA HAND2-AS1 distinguished early stage ESCC patients from healthy controls. lncRNA HAND2-AS1 overexpression resulted in downregulation of miRNA-21 in cells of ESCC cell lines and inhibited cell proliferation, migration, and invasion. miRNA-21 overexpression failed to affect lncRNA HAND2-AS1 expression but significantly attenuated the inhibitory effect of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration, and invasion. 30520131

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Cell migration and invasion experiments were performed to evaluate the effects of miR‑21 and MKK3 on the cell metastasis of melanoma. 31257538

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Under celastrol treatment, overexpression of microRNA-21 (miR-21) increased cell viability, migration, and invasion and inhibited cell apoptosis compared with negative control (p < .05, p < .01, or p < .001). 30989726

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE MiR-21 inhibitor showed reduced abilities of migration and invasion.ASPP2 was a target gene of miR-21. 31535570

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Inhibition of miR-21-5p inhibited cell proliferation and invasion, and promoted cell apoptosis. 31602231

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE MiR-21 can inhibit cell proliferation and invasion by regulated VHL in PTC cells. 31161410

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Here, co-transfection of miR-203-3p mimics and miR-21-5p inhibitors led to an extraordinary increased expression of miR-203-3p and synergistically inhibited proliferation, migration, and invasion in EC cells. 30134284

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Therefore, lncRNA-NEF may inhibit cancer cell migration and invasion in osteosarcoma by downregulating miRNA-21. 31186758

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE MiR-21 promotes the proliferation, migration and invasion and inhibits the apoptosis of breast cancer cells by inhibiting MAPK10. 31375553

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Therefore, TP73-AS1 may upregulate miR-21 to promote NSCLC cell migration and invasion. 31129247

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. 31384542

2019