Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE APE1 regulated invasion via upregulation of matrix metalloproteinase 14 (MMP-14), which subsequently activated MMP-2, leading to degradation of the extracellular matrix in a redox-dependent manner. 31308045

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Inhibitor treatment of metalloproteinases, as well as short hairpin RNA-mediated knockdown of Mmp14 strongly impacted TIC characteristics, including tumor initiation, cell growth, migration, and invasion, especially in starved environments. 30521382

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Furthermore, the results indicated that miR‑584‑5p inhibited the expression of MMP‑14 at the protein and mRNA levels. miR‑584‑5p also inhibited the expression of MMP‑4 and Slug, which are involved in tumor invasion and metastasis. 30628644

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Strikingly in this study, ampelopsin E was able to halt migration, transmigration and invasion in MDA-MB-231 cells by reducing formation of invadopodia and its degradation capability through significant reduction (<i>p</i> < 0.05) in expression levels of PDGF, MMP2, MMP9 and MMP14. 31323836

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE NOX5 increases intracellular reactive oxygen species (ROS) that, in turn, activate a HIF1/MMP14 pathway, which is responsible for the increased tumor cell invasion. 30606769

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Membrane type 1-matrix metalloproteinase (MT1-MMP) is a critical protease for local invasion and metastasis. 31519727

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Cell proliferation, migration, invasion and the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 14 (MMP-14) after transfection of miR-34a mimics or HNF4α siRNA into SH-SY5Y cells were detected by MTT assay, Transwell assay and Western blot assay, respectively. 31343368

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Thus, CCAT1 is a key oncogenic lncRNA associated with cervical cancer and plays a role in promoting cervical cancer cell proliferation and invasion by regulating the miR-181a-5p/MMP14 axis. 31084453

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE The effects of MT1‑MMP silencing on cell proliferation and invasion were detected through Cell Counting Kit‑8 test and Transwell assays. 30720114

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Collagen degradation and proMMP-2 activation are major functions of MT1-MMP to promote cancer cell invasion. 30522899

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Pharmacological inhibitors of PI3K/Akt signaling (LY294002 or A443654) reduced the expression of MT1-MMP and impaired BMSC invasion. 30659604

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE MT1-MMP is instrumental in SLFN5-controlled inhibition of cancer cell migration and invasion, as shown by MT1-MMP-knockdown and -overexpression analyses. 30844429

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Membrane type-1 matrix metalloproteinase (MT1-MMP) plays a crucial role in many physiological and pathological processes, especially in tumor invasion and metastasis. 30986050

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Increased invasiveness coincided with elevated expression of Wnt-target genes and established invasion driver matrix metalloproteinase MMP14. 30022447

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Matrix metalloproteinase 14 (MMP14), a membrane-associated matrix metalloproteinase, has been shown to influence the invasion and metastasis of several solid tumors. 31560170

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Mechanically, the overexpression of TUG1 significantly up-regulated the levels of MMP-14, VEGF, p-p38 mitogen-activated protein kinase (p-p38 MAPK) and p-HSP27 (heat shock protein 27), and promoted the proliferation, invasion and EMT of Cc cells. 31697952

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Recently, MMP14 was reported to be up-regulated in some types of cancer and to promote cancer cell invasion and metastasis. 30120968

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Loss of either one of these SNAREs leads to a reduction in surface MT1-MMP, gelatinase activity and reduced invasion. 31297933

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion. 31653854

2019

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE We hypothesized that quantification of membrane type-1 matrix metalloproteinase (MT1-MMP) levels in primary tumor tissue will provide a precise assessment of tumor regional lymph node invasion and remote organ metastasis. 30359513

2018

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE When MT1-MMP was reintroduced into MKN-45 and SGC-7901 cells in the KIF2A-siRNA group, only invasion inhibition effects on MKN-45 and SGC-7901 cells induced by KIF2A silencing can be reversed. 29781531

2018

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE MT1-MMP has long been involved in pancreatic cancer, especially in tumour invasion and metastasis. 30224904

2018

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. 29985410

2018

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Exo-150 decreased migration and invasion in RA FLS and downregulated tube formation in HUVECs by targeting MMP14 and VEGF. 30224512

2018

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Analysis of the proteins involved in the invasion showed that there is a significant reduction in the expressions of Rho guanine nucleotide exchange factor 7 (β-PIX), matrix metalloproteinase-9 (MMP-9), and membrane type 1 matrix metalloproteinase (MT1-MMP) in the presence of BHMC treatment at 12.5 µM. 29642589

2018