Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Activation of STAT3 promotes expansion of cancer stem cells in triple negative breast cancer. 31850822

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Particularly STAT3 and STAT5 are of interest in cancer biology. 31605750

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through a variety of mechanisms it can become constitutively activated in the pathogenesis of cancer. 31765941

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment. 31707338

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In this review, we will briefly introduce STAT3 protein and review its role in multiple aspects of cancer, and systematically summarize the recent advances in discovery of STAT3 inhibitors, especially the ones discovered in the past five years. 31810784

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Signal transducer and activator of transcription 3 (STAT3) is involved in many biological processes, including immunity and cancer. 31555812

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Signal transducer and activator of transcription 3 (STAT3) factor is associated with the development and progression of numerous types of human cancer. 31499589

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE This study provides a previous framework for combining this Stat3 inhibitor with RNAi designed to block immune checkpoint signaling for cancer therapy. 31692041

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Then the expression and activation signal transducer and activator of transcription 3 (STAT3), a key factor of EMT in cancer, were detected. 30820783

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE STAT3 isoforms: Alternative fates in cancer? 30031681

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In this review, we summarized the role of STAT3 in cancer and the tumor microenvironment, and present inhibitors of STAT3 signaling cascades.[BMB Reports 2019; 52(7): 415-423]. 31186087

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE STAT3 is constitutively activated in many malignant tumor types and plays an important role in multiple aspects of cancer aggressiveness. 31427441

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Our goal was to characterize the precise mechanism linking STAT3 with the activity of Akt and other AGC kinases in cancer using melanoma cells as a model. 30622697

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE We review here the role of STAT3/5 activation in solid cancers and summarize their association with survival in cancer patients. 31557897

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 PosttranslationalModification BEFREE Supporting redundancy of function by the two cytokines, CA-MSC induced STAT3 phosphorylation and increased cancer cell "stemness". 30305729

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Airway normal and cancer epithelial cells (16HBE and A549) were exposed to cigarette smoke extracts (CSE) or with/without agomiR-21, and then it was assessed: a) miR-21 expression; b) signal transducer and activator of transcription 3 (STAT3) nuclear protein expression and ERK1/2 activation; c) IL-8 gene expression and protein release. 31054160

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 PosttranslationalModification BEFREE We found that phosphorylation of STAT3 Y705 but not S727 promoted cancer cell EMT and metastasis through the Slug-mediated regulation of E-cadherin and Vimentin. 31597912

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Constitutive activation of signal transducer and activator of transcription 3 (STAT3) occurs in ∼70% of human cancers, and STAT3 is regarded as one of the most promising targets for cancer therapy. 31594861

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Signal transducer and activator of transcription 3 (STAT3), a previously accepted tumor-promoting protein in various malignancies, plays a key role in the process of cancer glycolysis. 31750256

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Correlation of expression levels of these markers in the oral cancer cohort of The Cancer Genome Atlas (n = 313) with treatment outcome identified 54 genes (p < 0.05 or fold change >2) associated with disease recurrence, 8 genes (NQO1, UBE2C, EDNRB, FKBP4, STAT3, HOXA1, RIT1, AURKA) being significant with high fold change. 30641296

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy. 31087190

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Depression induces secretion of neuropeptide Y from prostate cancer cells, which, in turn, recruits myeloid-derived suppressor cells (MDSC) to the tumor; tumor cells and MDSCs secrete IL6, which activates STAT3 within cancer cells. 30670491

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Furthermore, previous studies have reported that IL-6-STAT3 pathway is overexpressed in various types of cancer and contributes to cell proliferation, apoptosis, invasion/migration, chemoresistance and modulation of stemness features. 31824138

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE We hypothesized that EGFR downstream of STAT3 participates in HER3 expression because STAT3 contributes to cancer stemness and survival of EGFR-TKI resistant cancers. 31619200

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE <b>Conclusions:</b> These observations uncover a novel peritoneal metastatic activator and demonstrate the association between HOXA11, Stat3 and cancer stemness of gastric cancer cells, thereby revealing a previously undescribed mechanism of peritoneal metastasis. 31695791

2019