Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.550 Biomarker BEFREE A recent study showed that a combination of Y15 (a FAK autophosphorylation inhibitor) with temozolomide (TMZ) treatment was effective in glioblastoma (GBM) therapy. 31360198

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.550 PosttranslationalModification BEFREE Moreover, the dimeric bicyclic ligand induced cell detachment and inhibited FAK phosphorylation in U-373 MG glioblastoma cells. 31556442

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.550 AlteredExpression BEFREE In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAK<sup>p-Try397</sup>and its downstream pathway in glioblastoma cells. 27125297

2017

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.550 Biomarker BEFREE Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells. 26377974

2015

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.550 Biomarker BEFREE Thus, microarray gene expression analysis can be effective in establishing genes affected in response to FAK inhibitor alone and in response to combination of Y15 with temozolomide that is important for glioblastoma therapy. 23387973

2014