Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression BEFREE The GALAD score identified patients with any stage HCC with an AUC of 0.96 - significantly greater than values for serum levels of AFP (AUC, 0.88), AFP-L3 (AUC, 0.86) or DCP (AUC, 0.87). 31712073

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Alpha-fetoprotein is an autoantigen in hepatocellular carcinoma and juvenile Batten disease. 31585923

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression BEFREE Analyses of HBV-related HCC specimens showed that the expression of AFP was negatively correlated with the levels of miR-1236 and miR-329. 31680299

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Only <i>E-Cadherin</i> is an independent risk factor for prediction of HCC with low AFP. 31790342

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE In multivariate analysis, the CC genotype out-performed AFP is determining HCC.<b>Conclusion</b>: Apa1 CC genotype is linked to HCC in HCV C cirrhotic patients, and so has the potential to be an independent biomarker predictor for HCC occurrence in HCV cirrhosis. 31682785

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE All studies provided the sensitivity and specificity of GPC3 and the alpha-fetoprotein (AFP) in the HCC and LC diagnosis. 31113610

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE The multivariable analysis, however, found that the association between TDF and HCC no longer existed (SHR, 0.81; 95% CI, 0.42-1.56; P = 0.52) after adjustment for age, sex, country, albumin, platelet, α-fetoprotein, cirrhosis, and diabetes mellitus. 31634265

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE The area under curves (AUC) was calculated for each microRNA and compared with that for alpha-fetoprotein (AFP) in the detection of HCC at early stage. 31053500

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Independent predictors for HCC recurrence were male sex (p = 0.035), pre-operative liver cirrhosis (LC) (p = 0.025), serum creatinine  > 1.5 mg/dL (p = 0.045), post-operative 5th-year alpha-fetoprotein (AFP) > 15 ng/ml (p < 0.001), LC (p = 0.004), and ALBI grades 2 and 3 (p < 0.001). 31559485

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Clinical value of LHPP-associated microRNAs combined with protein induced by vitamin K deficiency or antagonist-II in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma. 31693242

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE This model may enhance early-stage HCC detection and help to overcome insufficient sensitivity of AFP. 31648804

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Prognostic stratification of patients undergoing resection for HCC within and beyond the BCLC resection criteria should include assessment of AFP and comorbidities for BCLC-0/A patients, as well as tumor burden for BCLC-B patients. 31696396

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Taken together, AFP and ORM1 in the urine may be used as a diagnostic or screening biomarker of HCC and studies on large samples are needed to validate the result. 31736338

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression BEFREE A model combining these 4 MRI factors with alpha-fetoprotein level had the best performance in predicting the identification of IDNs as HCCs in explanted livers. 31756026

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression BEFREE High UBE2Z expression was significantly correlated with age, advanced TNM stage, histological grade, vascular invasion, elevated serum alpha-fetoprotein expression (AFP), worse overall survival (OS) and disease-free survival (DFS) of HCC patients (all P < 0.05). 31831168

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE The overall Hepatocellular carcinoma (HCC) was found to be positively correlated with alkaline phosphatase, γ-glutamyltransferase, and alpha-fetoprotein and liver stiffness measurement values from stage A to stage D (P < .05). 31659795

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE In down-staging groups, AFP ≥ 100 (HR, 2.6; P = 0.02) was the only independent predictor of HCC recurrence. 31344273

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE AFP acetylation plays an important role in HCC progression and provides a new potential prognostic marker and therapeutic target for HCC. 31811908

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE The area under the curve of MRI alone and combination with AFP was not statistically different (Any-HCC: 0.905 vs. 0.924; Early-HCC: 0.853 vs. 0.885; Very early-HCC: 0.838 vs. 0.885, respectively, all P values >0.2). 31524775

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation BEFREE Significant predictors for HCC were identified using multiple Cox regression analysis in study cohort: treatment age ≥60 years (hazard ratio [HR]: 2.04, 95% confidence interval [CI] = 1.3-3.7), pretreatment bilirubin ≥1.1 mg/dL (HR: 1.99, 95% CI = 1.08-3.67), α-fetoprotein ≥7.9 ng/mL (HR: 2.44, 95% CI = 1.16-5.32), no sustained virological response (SVR; HR: 1.91, 95% CI = 1.05-3.45), and baseline cirrhosis (HR: 4.45, 95% CI = 2.07-9.73). 31800346

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation BEFREE CircPanel showed a higher accuracy than AFP (alpha-fetoprotein) to distinguish individuals with HCC from controls in all three sets (AUC, 0.863 [95% confidence interval, CI: 0.819-0.907] vs. 0.790 [0.738-0.842], p = 0.036 in training set; 0.843 [0.796-0.890] vs. 0.747 [0.691-0.804], p = 0.011 in validation set 1 and 0.864 [0.830-0.898] vs. 0.769 [0.728-0.810], p < 0.001 in validation set 2). 31456215

2020

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE The results showed that TRIM7 expression was elevated in human HCC tissues and that TRIM7 expression was significantly associated with tumor size, pTNM stage, serum α-fetoprotein (AFP) concentration, serum hepatitis B virus (HBV) DNA copy number and overall survival (OS) of HCC patients. 30850165

2019

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Protein induced by vitamin K antagonist-II (PIVKA-II), in addition to alpha-fetoprotein, is a useful tumor marker for diagnosis of hepatocellular carcinoma (HCC). 31131509

2019

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Postoperative α-fetoprotein response predicts tumor recurrence and survival after hepatectomy for hepatocellular carcinoma: A propensity score matching analysis. 30846192

2019

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker BEFREE Our study aims to detect the sensitivity of the new biomarker miR-212 existing in serum exosomes along with other hepatocellular carcinoma biomarkers such as AFP (alpha-fetoprotein), CA125 (carbohydrate antigen-ca125), and Hbx protein in the diagnosis of HBV-related liver diseases. 31608838

2019