Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma. 31170416

2019

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 PosttranslationalModification BEFREE Recently, we identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside (PGG) as a GNMT promoter enhancer compound in HCC. 30760754

2019

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC). 30850319

2019

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 PosttranslationalModification BEFREE Overall, our findings suggest that reduced Gnmt expression caused by promoter hypermethylation is one of the key molecular events in the development of NAFLD-derived HCC and that assessing Gnmt methylation level may be useful for disease stratification. 31086990

2019

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE The levels of miR-224 and GNMT mRNA showed a significant inverse relationship in tumor specimens from HCC patients. 30115977

2018

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE GNMT downregulation leads to loss of liver function progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. 30237481

2018

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE In this study, we investigated the activity of ectopic GNMT delivered using recombinant adeno-associated virus (AAV) gene therapy in mouse models of liver cirrhosis and HCC. 30217986

2018

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE These results reveal a novel mechanism in which GNMT participates in AKT signaling and HCC tumorigenesis by promoting HectH9-mediated PREX2 degradation. 28205209

2017

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Therefore, in this study, we aimed for the identification of a GNMT inducer for HCC therapy. 27153064

2016

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Glycine N-methyltransferase (GNMT) is a folate binding protein commonly diminished in human hepatoma yet its role in tumor development remains to be established. 23922098

2014

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE The findings in this manuscript indicate that DNA hypermethylation plays an important role in the repression of GNMT in HCC and that loss of GNMT in human HCC could promote the establishment of aberrant DNA methylation patterns at specific gene promoters. 23475283

2013

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE In addition, mutations in glycine-N-methyltransferase (GNMT) could be associated with a higher risk of hepatocellular carcinoma and liver disease due to an unbalanced S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio, which leads to aberrant methylation reactions. 23474979

2013

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE High proportions of GNMT knockout mice developed HCC. 23749938

2013

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE Children with GNMT mutation have elevated liver transaminases, and Gnmt knockout mice develop liver injury, fibrosis, and HCC. 23073625

2012

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Previously, we reported that glycine N-methyltransferase (GNMT) knockout (Gnmt(-/-)) mice develop chronic hepatitis and HCC. 22183894

2012

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 PosttranslationalModification BEFREE Reduced levels of GNMT and phosphorylation of AMPKα at Thr172 and increased levels of Ras, LKB1, and RASGRP3 in HCC samples from patients were associated with shorter survival times. 22687285

2012

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Integrated gene expression data revealed highest expression of proliferation-related CTGF, c-MYC, and PCNA, and lowest expression of BHMT, DMBT1, DUSP1, GADD45g, and GNMT, in more aggressive rat and human HCC. 22434528

2012

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE One hundred thirty-three DNA samples (45 cirrhotic nodules, 29 LGDNs, 13 HGDNs, 14 eHCCs, and 32 progressed HCCs (pHCCs)) from HBV-infected resected livers were subjected to MethyLight analysis for nine CpG island loci (APC, RASSF1A, SOCS1, P16, COX2, SPRY2, PTEN, GNMT, and ERK), and COX2, RASSF1A, and SOCS1 protein expression status was analyzed by immunohistochemistry. 21145824

2011

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Therefore, GNMT is a tumor suppressor for HCC and it exerts protective effects in hepatocytes via direct interaction with AFB(1), resulting in reduced AFB(1)-DNA adducts formation and cell death. 19146867

2009

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Previously, we described that the expression of GNMT was diminished in human HCC. 19035462

2009

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE In a previous study, we showed that GNMT acts as a susceptibility gene for hepatocellular carcinoma. 17332283

2007

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE However, in this study, we did not observe the association of polymorphic GNMT alleles as inherited risk factors for HCC. 12566309

2003

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Therefore, the expression of GNMT was downregulated in human HCC. 12566990

2003

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Previously, we reported that the expression level of GNMT was diminished in human hepatocellular carcinoma. 10843803

2000

Entrez Id: 27232
Gene Symbol: GNMT
GNMT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. 9495250

1998