Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE Unlike FGF19, FGF15 did not induce hepatocellular carcinomas (HCC) in three mouse models of metabolic diseases (db/db, diet-induced obese, and multi-drug resistance 2 [Mdr2]-deficient mice), even at supra-pharmacological exposure levels. 28189755

2017

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE Mice with Abcb4 ablation accumulate toxic BA within the bile ducts and present HCC. 28894223

2017

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 GeneticVariation BEFREE We investigated the chemopreventive potential of S-adenosylmethionine (SAM), an essential donor for all methylation reactions in the cell, at the late precancerous stage of HCC development using the Mdr2-knockout (Mdr2-KO, Abcb4<sup>-/-</sup>) mice, a model of inflammation-mediated hepatocarcinogenesis. 29285212

2017

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE In Mdr2-deficient mice, which spontaneously developed HCC, the loss of IL-6 in monocytes/KCs resulted in inhibition of IL-6/signal transducer and activator of transcription 3 signaling, decreased serum IL-6 levels, and delayed tumorigenesis. 27589954

2016

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE Here, we explore the connection between chronic inflammation and DNA methylation in the liver at the late precancerous stages of HCC development in Mdr2(-/-) (Mdr2/Abcb4-knockout) mice, a model of inflammation-mediated HCC. 25918251

2015

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE Mice lacking S100a9 were crossed with the Mdr2(-/-) model, a prototype of inflammation-induced HCC formation. 25331529

2015

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 GeneticVariation BEFREE Now, to explore the molecular mechanisms underlying the tumor-promoting effect of PHx, we compared genomic and transcriptomic profiles of HCC tumors developing in the Mdr2-KO mice either spontaneously or following PHx. 25401338

2014

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE ST18 was also frequently amplified in HCC nodules from Mdr2(-/-) mice, supporting its assignment as a candidate liver oncogene. 23540693

2013

Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.590 Biomarker BEFREE Expression of P-gps (multidrug export pump MDR1 (ABCB1), phospholipid flippase MDR3 (ABCB4), sister of P-glycoprotein SPGP (ABCB11)) and basolateral MRP homologue MRP3 (ABCC3) showed a trend for decreased levels in HCC but was highly variable among individual tumors. 15780063

2005