Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma. 31698037

2020

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Circ_0015756 knockdown was shown to increase the expression of miR-7, reduce the proliferation, invasion, migration and resistance to apoptosis, and down-regulate the expression of FAK in HCC. 31522588

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE The present data suggest that PTK2 may be a novel prognostic biomarker for HCC recurrence, and a therapeutic target for HCC treatment. 30849480

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE BI-3663 (cereblon-based) degrades PTK2 with a median DC<sub>50</sub> of 30 nM to >80% across a panel of 11 HCC cell lines. 30739444

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Additionally, high expression of both cPLA2α and p-FAK predicted the worst prognoses for HCC patients. 31516757

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Taken together, our data demonstrate a novel function of LOXL4 in tumor metastasis mediated by exosomes through regulation of the FAK/Src pathway and angiogenesis in HCC. 30704479

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE The focal adhesion kinase (FAK) gene protein tyrosine kinase 2 is amplified in 16.4% of The Cancer Genome Atlas HCC specimens, and its amplification leads to increased FAK mRNA expression. 31069844

2019

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma. 30292831

2018

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE DBH-AS1 facilitated the development of HCC via miR-138/FAK/Src/ERK pathway, establishing the molecular basis of DBH-AS1 in clinical application for HCC. 30142544

2018

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway. 29746931

2018

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Mitochondrial fission promotes cell migration by Ca<sup>2+</sup> /CaMKII/ERK/FAK pathway in hepatocellular carcinoma. 29210177

2018

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Interestingly, western blot analysis showed that treatment with oxaliplatin increased GAS7C and N-WASP protein levels and decreased the levels of proteins involved in the fibronectin/integrin/FAK pathway, such as FAK, in both HCC cell lines. 28475688

2017

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE In conclusion, Rab5a is overexpressed in human HCC and contributes to cancer cell proliferation and invasion through regulation of FAK and AKT signaling. 26443539

2016

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Moreover, the expression levels of beta-catenin, cyclin D1, c-Myc, MMP-2, and FAK detected by western blotting were downregulated in SLC5A8-transfected HCC cells compared with control-transfected cells, indicating that SLC5A8 has a tumor-suppressive function that acts by interfering with Wnt/β-catenin signaling in HCC. 27465549

2016

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE MACC1 or combination of MACC1/FAK could serve as a novel biomarker in predicting the prognosis of HCC after LT. 24516351

2014

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE It was also shown that the combination of SKI II and U0126 further attenuated the migration of hepatoma HepG2 cells via FAK/MLC-2 signaling pathway. 23545258

2013

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE In addition, miR-151 can function synergistically with FAK to enhance HCC cell motility and spreading. 20305651

2010

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE We also found that the phosphorylation levels of FAK in both of the hepatoma cell lines were higher than that in L02 hepatic cells. 15532706

2004

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE In conclusion, PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC. 14578863

2003