Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE Mutations of the human telomerase reverse transcriptase promoter-known to drive malignant transformation of <i>CTNNB1</i>-mutated HCA-seem to be dispensable for <i>RSPO2</i> rearranged HCA and HCC. 30901310

2019

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Mutation of the TERT promoter is one of the most common genetic alterations in hepatocellular carcinoma (HCC), indicating that TERT upregulation is a critical event in hepatocarcinogenesis. 30447097

2019

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Consistently, TERT expression levels in RNs were comparable to those in normal livers, whereas every HCC tissue demonstrated an elevated level of TERT expression. 30756187

2019

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Part of the telomerase complex, telomerase reverse transcriptase, is encoded by TERT, and several mechanisms of telomerase reactivation have been described in HCC that include somatic TERT promoter mutations, TERT amplification, TERT translocation and viral insertion into the TERT gene. 31253940

2019

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE Although main HCC oncogenic drivers have been deciphered in recent years (TERT, TP53, CTNNB1 mutations, miR122 and CDKN2A silencing), therapeutic applications derived from this molecular knowledge are still limited. 31783782

2019

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE The proliferation ratio of HCC cells transfected with TERT-siRNA was significantly decreased compared with control group. 29707886

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE The analysis of the Cancer Genome Atlas (TCGA)<sup>4</sup> dataset showed that higher levels of TERT and DNMT3B expression predicted significantly shorter survival in HCC patients. 30017965

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE High blood levels of malondialdehyde, total antioxidant capacity, caspase-cleaved cytokeratin-18, soluble CD40 ligand, substance P, C-reactive protein, and vascular endothelial growth factor, increased neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in blood, high peripheral blood expression of human telomerase reverse transcriptase messenger ribonucleic acid, and high HCC expression of dickkopf-1 have recently been associated with decreased survival rates. 30310256

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE High PI3Kδ levels in HCC were found to correlate with poor survival rates, with human advanced HCC showing positive correlations between the protein levels of oxidized SERPINA3, PI3Kδ, and TERT. 30300952

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE The purpose of the present study was to identify major histocompatibility complex class II-restricted helper T cell epitopes derived from human telomerase reverse transcriptase in patients with hepatocellular carcinoma. 29405561

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Our data suggest that TERT promoter mutations can enhance the promoter activity in HCC cell lines expressing PROX1 but are not the predominant mechanism of TERT upregulation in B viral HCC patients, based on the inhibition of PROX1-dependent transcriptional activation by HBx. 29987895

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE In summary, constitutional variants resulting in amino acid changes in the telomerase reverse transcriptase were found in a small proportion of patients with cirrhosis-associated HCC. 28813500

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE In this study, we pulled down and identified RBFOX3 (RNA binding protein fox-1 homolog 3) as a novel hTERT promoter-binding protein in HCC cells using biotin-streptavidin-agarose pull-down and proteomics approach, and validated it as a regulatory factor for hTERT signaling and tumor growth in HCCs. 28839469

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE The correlation analysis revealed a significantly negative correlation between miR-138 and telomerase reverse transcriptase (TERT) mRNA expression in HCC. 28258280

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE <i>TERT-CLPTM1</i> locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma. 29042796

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE In contrast, upregulation of CTCF was positively correlated with FOXM1 and TERT expression in clinical HCC biopsies. 28862757

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE In this study, we identified hTERTR-FAM96A (human telomerase reverse transcriptase-family with sequence similarity 96 member A) as a new efficient agent for apoptosome-activating and anti-tumor protein and investigated the potential tumor suppressor function in hepatocellular carcinoma. 28443470

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE Here we analyzed the TERT promoter status and genotyped the TERT SNPs at rs2736098 and rs2736100 in patients with HCC. 28416747

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Interestingly immunohistochemical analysis demonstrated a higher positive rate of TERT cytoplasmic localization (95%) than nuclear localization (64%) in HCCs. 28460432

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE The aim of this study was to examine telomere length and germline hTERT mutations as associated with NAFLD-HCC. 28677271

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE We also showed that telomerase reverse transcriptase promoter (TERTp) mutation correlated with telomere shortening in HCC. 28833123

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE TERT overexpression was the only significant prognostic factor for late IHR in HCC treated with curative resection. 28947783

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE TERT promotermutations were significantly more frequent in hepatocellular carcinomas related to hepatitis C virus infection (5/6; 83.3%) compared to tumors of other etiologies (P = 0.001). 27661004

2016

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE TERT protein levels were higher in HCC (n = 28) compared to normal liver tissues (n = 8) (p =0.001), but did not differ between mutated and non-mutated tumor tissues. 27056898

2016

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE Several lines of evidence suggest that this process is involved in liver disease progression: (a) telomere shortening and alterations in the expression of proteins protecting the telomere are associated with cirrhosis and hepatocellular carcinoma; (b) advanced liver damage is a feature of a spectrum of genetic diseases impairing telomere function, and inactivating germline mutations in the telomerase complex (including human Telomerase Reverse Transcriptase (hTERT) and human Telomerase RNA Component (hTERC)) are enriched in cirrhotic patients independently of the etiology; and (c) experimental models suggest that telomerase protects from liver fibrosis progression. 26999107

2016