Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review. 31612830

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Taken together, the ERBB3 kinase activity contributes to the outgrowth of ileal organoids and intestinal tumorigenesis, and the development of ERBB3 kinase inhibitors, including epidermal growth factor receptor family members, can be a potential way to target colorectal cancer. 31724799

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE We analyzed the EGFR signaling network, which plays an essential role in colorectal cancer, and studied its dynamics within 24 h upon treatment with the EGFR blocking antibody cetuximab, representing the first cellular adaption towards therapy. 31814417

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The combination of fluorouracil and irinotecan with a BRAF<sup>V600E</sup> and EGFR inhibitor may have synergistic action, leading to recession of secondary metastases in patients with BRAF<sup>V600E</sup>-mutated colorectal cancer. 30662270

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Adjuvant Chemotherapy With or Without Biologics Including Antiangiogenics and Monoclonal Antibodies Targeting EGFR and EpCAM in Colorectal Cancer: A Systematic Review and Meta-analysis. 30782542

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition. 30858928

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy. 31287988

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis. 30576064

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Cetuximab is a chimeric monoclonal antibody against epidermal growth factor receptor (EGFR) and it is approved for treatment of human colorectal cancer and squamous cell carcinoma of head and neck. 31112673

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Sixty patients with lung or colorectal cancer who were receiving EGFR inhibitors were prospectively followed for at least one year by oncologists and dermatologists. 29549700

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE These results indicated that YB‑1 plays an important role in cell proliferation, migration, apoptosis and EGFR expression in colorectal cancer. 30864697

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Limited options of targeted therapy for colorectal cancer narrowly focus on blocking cancer-generic targets VEGFR and EGFR. 30754629

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer. 31563999

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12. 30671888

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE TF/FVIIa (Tissue Factor/Active Coagulation factor VII) and EGFR (Epidermal Growth Factor Receptor) signaling both promote malignant progression of colorectal cancer. 30462558

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Circulating Tumor DNA Detection in the Management of Anti-EGFR Therapy for Advanced Colorectal Cancer. 30967998

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The optimal management of hypomagnesemia (hMg) induced by epidermal growth factor receptor inhibitors (egfris) for advanced colorectal cancer is unclear. 31043822

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Repurposing EGFR Inhibitor Utility in Colorectal Cancer in Mutant <i>APC</i> and <i>TP53</i> Subpopulations. 31015202

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The high expression of EGFR was due to the downregulation of NR1H3 which is a novel molecular mechanism in the development of colorectal cancer. 31104333

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. 30252132

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer. 30478887

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE SIGNIFICANCE: Menin acts as a calcium-responsive regulator of SKP2 expression, and small molecule EGFR inhibitors, which induce calcium release, synergize with Menin inhibition to reduce SKP2 expression and suppress colorectal cancer. 30877106

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE This study, therefore, identified five candidate microRNAs, two hub genes (CTNNB1 and epidermal growth factor receptor), and seven significant target genes associated with colorectal cancer. 31718480

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Broad-spectrum receptor tyrosine kinase inhibitors overcome <i>de novo</i> and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer. 30863492

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE miR-145-5p restrained cell growth, invasion, migration and tumorigenesis via modulating RHBDD1 in colorectal cancer via the EGFR-associated signaling pathway. 31693935

2019