Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE In Denmark, the national HNPCC register has been granted an exception to send unsolicited letters with information on hereditary colorectal cancer and an invitation to genetic counseling to members of families with familial and hereditary colorectal cancer. 29651783

2019

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE After filtering, 15 pathogenic germline variants (9.9%) were found in 15 patients, arising from 9 genes of varying penetrance for colorectal cancer (APC (n = 2; 13%), ATM (n = 1; 6%), BRCA1 (n = 2; 13%), CDH1 (n = 2; 13%), CHEK2 (n = 4; 27%), MSH2 (n = 1; 7%), MSH6 (n = 1; 7%), NF2 (n = 1; 7%), and TP53 (n = 1; 7%)). 30730459

2019

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We transiently expressed MLH1 or MSH2 variants in MLH1- or MSH2-null human colorectal cancer cell lines (HCT116 or LoVo), respectively. 30998989

2019

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Additional loss of MSH2 and MSH6 expression in sporadic deficient mismatch repair colorectal cancer due to MLH1 promoter hypermethylation. 30723092

2019

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The primary objective of the present study was to compare the choice of colectomy, i.e. total vs. segmental colectomy, in cases of hereditary non-polyposis colorectal cancer (HNPCC/lynch syndrome), and to assess the efficacy, oncological safety, functional outcome and post-operative complications of total abdominal colectomy with ileorectal anastomosis vs. segmental colectomy in HNPCC. 30186378

2018

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The First Molecular Screening of MLH1 and MSH2 Genes in Moroccan Colorectal Cancer Patients Shows a Relatively High Mutational Prevalence. 30044143

2018

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Analysis of human MutS homolog 2 missense mutations in patients with colorectal cancer. 29731845

2018

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Prognostic Value of E-cadherin-, CD44-, and MSH2-associated Nomograms in Patients With Stage II and III Colorectal Cancer. 28126685

2017

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Among MSH2 mutation carriers, mutations in MSH2 (the most prevalent mutations overall) were most commonly associated with female-specific cancers: endometrial cancer in 83 (30%) of 279 women; ovarian cancer in 28 (10%) of 279 women; and colorectal cancer in 239 (50%) 479 men and women. 28772289

2017

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). 27234654

2016

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Intronic and promoter polymorphisms of hMLH1/hMSH2 and colorectal cancer risk in Heilongjiang Province of China. 25560462

2015

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE On average, one in 71 male and one in 102 female MLH1 or MSH2 mutation carriers in their 20s will be diagnosed with colorectal cancer in the next 5 years. 25534380

2015

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Using data from the Colon Cancer Family Registry, we compared the proportion of childhood cancers (diagnosed before 18 years of age) in the first-, second-, and third-degree relatives of 781 probands with a pathogenic mutation in one of the MMR genes; MLH1 (n = 275), MSH2 (n = 342), MSH6 (n = 99), or PMS2 (n = 55) or in EPCAM (n = 10) (Lynch syndrome families), with that of 5073 probands with MMR-deficient colorectal cancer (non-Lynch syndrome families). 25963852

2015

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome. 26053027

2015

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Promoter methylation and immunohistochemical expression of hMLH1 and hMSH2 in sporadic colorectal cancer: a study from India. 24317816

2014

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The prognostic significance of polymorphisms in hMLH1/hMSH2 for colorectal cancer. 24793746

2014

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 PosttranslationalModification BEFREE Prognostic significance of hMLH1/hMSH2 gene mutations and hMLH1 promoter methylation in sporadic colorectal cancer. 24990217

2014

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer. 25561800

2014

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Our studies disclose an increased HNPCC-extracolonic tumors incidence and improved overall survival in MSS-HNPCC families. 24061861

2014

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. 24204293

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Germ-line mutations in the DNA mismatch repair genes MLH1, MSH2, and MSH6 predispose to the development of colorectal cancer (Lynch syndrome or hereditary nonpolyposis colorectal cancer). 24090359

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The risk of colorectal cancer in carriers of such EPCAM deletions is comparable to that of MSH2 mutation carriers, and is in accordance with a high expression of EPCAM in colorectal cancer stem cells. 23264089

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Novel DNA variants and mutation frequencies of hMLH1 and hMSH2 genes in colorectal cancer in the Northeast China population. 23573243

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Lynch syndrome (hereditary non-polyposis colorectal cancer; HNPCC) is an autosomal dominant cancer predisposition syndrome with high penetrance. 23255519

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The cumulative risk for all Lynch syndrome-related cancers at age 70 was 93.8 % for both hMLH1 and hMSH2 mutation carriers, and 81.7 % and 93.1 % for colorectal cancer at this age, respectively. 23640085

2013