×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Further, the role of PI3K /Akt/mTOR inhibitors alone and in combination with other chemotherapeutic drugs, in alleviating colorectal cancer is also discussed.
31215384
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K /AKT/mTOR pathway blockage.
31357480
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
In short, COX-2 or 5-LOX deletion and its inhibitors enhanced activity of PTEN and suppressed cell and adenoma progression through PI3K /AKT pathway in colorectal cancer .
29339153
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
CCR7 high expression leads to cetuximab resistance by cross-talking with EGFR pathway in PI3K /AKT signals in colorectal cancer .
31815051
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K -AKT signaling axis.
30832706
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Anthocyanins Prevent and Inhibit Colorectal Cancer through PI3K /AKT/survivin Signaling Pathway.
31830892
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
We selected MAPK- and PI3K -pathway inhibition in colorectal cancer as a model system to dissect out mechanisms of resistance.
30905967
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K /Akt signalling in colorectal cancer .
30472186
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
H19 regulates PI3K -Akt signal pathway through a competing endogenous RNA network and predicts poor prognosis in colorectal cancer .
31164794
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer .
30623365
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines.
30691487
2019
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
The PI3K /AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer .
29068474
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Assessment of PI3K /AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies.
29422975
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer .
29496520
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Although TANKYRASE (TNKS) inhibitors have been proposed as promising candidates, there are many colorectal cancer models that do not respond positively to TNKS inhibition <i>in vitro</i> and <i>in vivo</i> Therefore, a combinatorial therapeutic approach combining a TNKS inhibitor (G007-LK) with PI3K (BKM120 ) and EGFR (erlotinib) inhibitors in colorectal cancer was investigated.
29222171
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer .
30129057
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
DCLK1 promotes epithelial-mesenchymal transition via the PI3K /Akt/NF-κB pathway in colorectal cancer .
29277893
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Pathway analysis revealed multiple pathways including Jak-STAT, TGF-beta, PI3K -Akt and MAPK signaling pathway that are correlated to colorectal cancer .
29496555
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K /AKT Signaling Axis in the Pathogenesis of Colorectal Cancer .
30636581
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K /Akt Signaling Pathway in Colorectal Cancer .
29260353
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
uc.338 targets p21 and cyclin D1 via PI3K /AKT pathway activation to promote cell proliferation in colorectal cancer .
29901203
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Previously, we showed that activation of PI3K /Akt/mTOR contributes to colorectal cancer growth and metastasis.
29666061
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K /Akt/mTOR pathway in colorectal cancer progression.
29970122
2018
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K /AKT signaling.
28352192
2017
×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
These results suggest that regulation of the apoptosis, invasion and migration of colorectal cancer cells by GRA might be through suppressing PI3K and STAT3 signaling pathways. the present study indicated that GRA could be a potential effective therapy for patients with colorectal cancer .
28656212
2017