Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE LL1 could be a promising therapeutic drug candidate for colorectal cancer by inhibiting the STAT3 activation. 31499589

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Our results showed that miR-29a-5p was significantly upregulated and was accompanied by STAT3 activation in the colon tissues of CAC mouse and human colorectal cancer tissues, as compared with normal colon tissues. 31750910

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The expressions of p-JAK2 and p-STAT3 were significantly down-regulated 48 h after 20 µM of JAK2 specific inhibitor (AG490) was added to HCT116 cells (p < 0.05). 31472054

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE This study suggests that PLK3 inhibits glucose metabolism by targeting HSP90/STAT3/HK2 signaling and PLK3 may serve as a potential therapeutic target in colorectal cancer. 31655629

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Carboxypeptidase A4 promotes cell growth via activating STAT3 and ERK signaling pathways and predicts a poor prognosis in colorectal cancer. 31279884

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE These results indicate that PTPN9 inhibits cell growth and survival by repressing the activation of Stat3 in colorectal cancer, which suggests an important underlying mechanism of regulating cell growth and provides a novel candidate therapeutic target for colorectal cancer. 30804683

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway. 30979816

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE However, there are currently no effective STAT3 inhibitors in clinical practice for the treatment of colorectal cancer. 31576111

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer. 31506552

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer. 31435638

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Downregulation of RNF6 impaired the colorectal cancer cell proliferation and invasion <i>in vitro</i> and <i>in vivo</i> RNF6 may activate the JAK/STAT3 pathway and increase pSTAT3 levels by inducing the ubiquitination and degradation of SHP-1.<b>Conclusions:</b> Genomic amplification drives RNF6 overexpression in colorectal cancer. 29288235

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. 29860266

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-x<sub>L</sub> and BID Protein Expression by Modulating Signaling Proteins Erk<sup>1/2</sup> and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. 28438053

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Although there was no difference in overall survival between groups in the overall unselected population, STAT3 might be an important target for the treatment of colorectal cancer with elevated pSTAT3 expression. 29397354

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. 30333916

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Our findings provide insight into the important role of SIRT2 in colon tumour angiogenesis and suggest that SIRT2/STAT3/VEGFA might be a novel prognostic biomarker and a potential therapeutic target for patients with colorectal cancer. 30584257

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. 30107178

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE <b>Results:</b> Downregulated PIAS3 expression, upregulated miR-18a expression and highly activated NF-κB and STAT3 were observed in colon tissues of CAC/CRC patients and AOM-DSS-induced mice. 29896300

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3. 29884911

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells. 28179289

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The aim of the present study was to elucidate the association between JAB1 and STAT3 expression and recurrence in colorectal cancer. 29113268

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE HSP110 promotes colorectal cancer growth through STAT3 activation. 27819670

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The present study examines the relationship between tumor total STAT3 and phosphorylated STAT3<sub>Tyr705</sub> (pSTAT3) expression, host inflammatory responses, and survival in patients undergoing resection of stage I-III colorectal cancer.<b>Experimental Design:</b> Immunohistochemical assessment of STAT3/pSTAT3 expression was performed using a tissue microarray and tumor cell expression divided into tertiles using the weighted histoscore. 27678454

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE We found that using interleukin 6 to induce p-STAT3 activation in colorectal cancer cell lines can result in vasculogenic mimicry and using AG490 to suppress p-STAT3 activation restrained vasculogenic mimicry. 29333928

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE In this study, we report a novel STAT3 to NCK1 signaling pathway in colorectal cancer (CRC). 28455144

2017