Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE VEGF inhibitors don't contribute to increased D-dimer levels in colorectal cancer patients without VTE. 31662546

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE A higher percentage of EPCs within the white blood cell fraction (total % EPCs / white blood cells (WBC)) and higher serum concentrations of VEGF were present in patients with MSI-H colorectal cancer, and not with MSS cancers (P < .001).MSI-H patients with colorectal cancer metastases are associated with the overexpression of circulating EPCs and VEGF, potentially driving angiogenesis. 30608431

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Moreover, MIR4435-2HG might participate in the development of colorectal cancer via the P38/MAPK and VEGF pathway. 30972258

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. 31757048

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Synchronous vascular endothelial growth factor protein profiles in both tissue and serum identify metastasis and poor survival in colorectal cancer. 30862805

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer. 31297348

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A. 31300350

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Angiogenic and Antiangiogenic VEGFA Splice Variants in Colorectal Cancer: Prospective Retrospective Cohort Study in Patients Treated With Irinotecan-Based Chemotherapy and Bevacizumab. 31402291

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a vascular endothelial growth factor (VEGF) receptor-2 antagonist, has been used previously either alone or in combination with chemotherapeutic drugs for treating colorectal cancer in a mouse model. 31594790

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE miR-622 inhibits angiogenesis by suppressing the CXCR4-VEGFA axis in colorectal cancer. 30851425

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE In conclusion, CCR6 facilitates tumor angiogenesis via the AKT/NF-κB/VEGF pathway in colorectal cancer. 29097259

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. 30037719

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis. 29983872

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Furthermore, Angiotensin receptor inhibitors (ARIs) and angiotensin-converting enzyme Inhibitors (ACE-Is) demonstrate activity in CRC by their inhibition of both Insulin-like growth factor 1 (IGF-1) and Vascular endothelial growth factor (VEGF), and therefore present a potentially novel therapeutic strategy in colorectal cancer, which have summarized in the current review. 30636592

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The aim of the present study is to evaluate clock (cry1, cry2 and per2) and clock-controlled (vascular endothelial growth factor-a, early growth response protein 1 and estrogen receptor β) gene expression in colorectal cancer and adjacent tissue and identify a possible link between survival of patients and expression of above mentioned genes. 29953268

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE 5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer. 29052437

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Our findings provide insight into the important role of SIRT2 in colon tumour angiogenesis and suggest that SIRT2/STAT3/VEGFA might be a novel prognostic biomarker and a potential therapeutic target for patients with colorectal cancer. 30584257

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE <b>Purpose:</b> There is extensive cross-talk between VEGF- and EGFR-pathway signaling in colorectal cancer. 29490990

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer. 29958090

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Circulating Levels of VEGF and CXCL1 Are Predictive of Metastatic Organotropismin in Patients with Colorectal Cancer. 28870907

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Collagen IV expression was analysed in response to VEGF inhibition in liver metastasis of colorectal cancer (CRC) patients, in syngeneic (Panc02) and xenograft tumours of human colorectal cancer cells (LS174T). 28141797

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE DHX32 Promotes Angiogenesis in Colorectal Cancer Through Augmenting β-catenin Signaling to Induce Expression of VEGFA. 28330603

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients. 28298545

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal cancer. 28602978

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes. 28403223

2017