Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Notch signaling in the brain: in good and bad times. 23570941

2013
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Characterising and predicting haploinsufficiency in the human genome. 20976243

2010
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. 21092311

2010
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Chronic DLL4 blockade induces vascular neoplasms. 20147986

2010
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Notch signaling controls liver development by regulating biliary differentiation. 19369401

2009
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. 17311993

2007
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. 17296941

2007
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Notch signaling is essential for ventricular chamber development. 17336907

2007
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. 17728344

2007
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. 16773578

2006
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Notch signaling, brain development, and human disease. 15817497

2005
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. 15923152

2005
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. 15466160

2004
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. 15520367

2004
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Dosage-sensitive requirement for mouse Dll4 in artery development. 15466159

2004
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. 12482957

2003
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. 12574630

2003
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Notch signaling is required for arterial-venous differentiation during embryonic vascular development. 11585794

2001
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Dll4, a novel Notch ligand expressed in arterial endothelium. 10837024

2000
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Notch signaling: cell fate control and signal integration in development. 10221902

1999
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR Neurogenic genes and vertebrate neurogenesis. 8794055

1996
Entrez Id: 54567
Gene Symbol: DLL4
DLL4
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 GeneticVariation CLINVAR The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. 8756291

1996