Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET Several genes within this GAD1 regulatory network show diagnosis- and sector-specific expression changes within the circuitry of the hippocampus, influencing abnormal GAD1 expression in schizophrenia and bipolar disorder. 25738424

2015

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons. 25364290

2014

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET The copy number intensities examined using both microarrays and quantitative real-time polymerase chain reaction for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. 22309971

2012

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET The nature of these changes is quite different in schizophrenia and bipolar disorder, suggesting that a common cell phenotype (in this case, decreased GAD₆₇ expression) may involve two fundamentally different molecular endophenotypes and reflect unique susceptibility genes involved in the respective disorders. 21184762

2011

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET This molecular remodeling may contribute to the induction of reelin (RELN) and GAD(67) (GAD1) promoter demethylation, and may reverse the downregulation of various GABAergic mRNAs and proteins detected in the telencephalon of patients with schizophrenia or bipolar disorders. 22122643

2009

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956

2005