Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. 22102614

2012
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT MSH6 mutation carriers have later age of onset of both colorectal cancer (62 vs. 51 years) and endometrial cancer (58 vs. 48 years) and a larger proportion of endometrial cancer than MLH1 or MSH2 mutation carriers. 14961575

2004
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Later age of disease onset and lower incidence of colorectal cancer may contribute to a lower proportion of identified MSH6 mutations in families suspected of HNPCC. 15483016

2004
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT MSH6 germline mutations are rare in colorectal cancer families. 14520694

2003
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic? 12522549

2003
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT In contrast to hMLH1 and hMSH2, little is known about the overall involvement of hMSH6 in colorectal cancer. 11807791

2002
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. 11709755

2002
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. 11470537

2001
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Do MSH6 mutations contribute to double primary cancers of the colorectum and endometrium? 11153917

2000
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer. 10699937

2000
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT When mutations in hMSH6 were included, more than 80% of Chinese colorectal cancer patients younger than 31 years had germline mutations in mismatch repair genes. 10413423

1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation UNIPROT Our data suggest that germ-line msh6 mutations predispose individuals to primarily late-onset, familial colorectal carcinomas that do not fulfill classic criteria for HNPCC. 10537275

1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker GENOMICS_ENGLAND