Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.800 Biomarker CTD_human Tumour samples from 73 CRC patients who were treated in advanced stage with either irinotecan alone or in combination with 5-FU/leucovorin, were analysed for expression of Bcl-2, hMLH1 and hMSH2 using immunohistochemistry. 18949393

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.800 GeneticVariation UNIPROT We sequenced the MLH1/MSH2 coding and promoter core regions in CRC patients diagnosed below age 40, and/or with multiple primary cancers or familial cancer clustering suggestive of HNPCC, and correlated deleterious mutations with clinical and tumour features. 15996210

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.800 GeneticVariation UNIPROT These results indicate that there are different oncogenic pathways in the MSI sporadic colorectal cancers with germline missense mutations in the hMSH2 gene. 12792735

2004

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.800 GeneticVariation UNIPROT Prevalence of MLH1/MSH2 mutations in CRC families was significantly increased by the presence of: (i) fulfilled Amsterdam criteria; (ii) four or more CRCs; or (iii) one or more endometrial cancer. 14504054

2003

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.800 GeneticVariation UNIPROT Only one missense mutation of the hMSH2 gene was identified in 45 patients (2 percent) with sporadic early-onset colorectal cancer. 9559627

1998

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.800 Biomarker GENOMICS_ENGLAND