Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker PSYGENET Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. 23529111

2013

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker PSYGENET Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression. 22475622

2013

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker PSYGENET Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. 22378896

2012

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker PSYGENET In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early-life adversity has been posited to underlie the subsequent development of major depression. 20692103

2011

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker PSYGENET Our results suggest that the aberrant REST-mediated transcriptional regulation of, at least, CRH, adenylate cyclase 5, and tumor necrosis factor superfamily, member 12-13, might be state-dependent and associated with the pathophysiology of major depression. 19846118

2010

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. 18698320

2009

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. 12438692

2002