Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human VEGFC and VEGFR1 mRNA overexpression is of prognostic value, dependent on HER2 status, in patients with high-risk early breast cancer undergoing adjuvant treatment. 26124351

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human VEGFC and VEGFR1 mRNA overexpression is of prognostic value, dependent on HER2 status, in patients with high-risk early breast cancer undergoing adjuvant treatment. 26124351

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. 25221644

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. 25221644

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Molecular profiling of single circulating tumor cells with diagnostic intention. 25358515

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Molecular profiling of single circulating tumor cells with diagnostic intention. 25358515

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. 22302033

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer. 21638049

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. 22302033

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer. 21638049

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Taken together, our present results suggest that pterostilbene may serve as a chemopreventive agent to inhibit HRG-β1/HER2-mediated aggressive and invasive phenotype of breast carcinoma through down-regulation of MMP-9, p38 kinase and Akt activation. 19617202

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Immunophenotypic predictive profiling of BRCA1-associated breast cancer. 20941507

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Immunophenotypic predictive profiling of BRCA1-associated breast cancer. 20941507

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Taken together, our present results suggest that pterostilbene may serve as a chemopreventive agent to inhibit HRG-β1/HER2-mediated aggressive and invasive phenotype of breast carcinoma through down-regulation of MMP-9, p38 kinase and Akt activation. 19617202

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Subtype IV breast cancer was positive for ER with a full-range expression of HER2, responding poorly to CMF; however, this subtype showed excellent survival when treated with CAF. 21501481

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Subtype IV breast cancer was positive for ER with a full-range expression of HER2, responding poorly to CMF; however, this subtype showed excellent survival when treated with CAF. 21501481

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Surgical specimens from estrogen receptor-positive breast cancer and adjacent normal breast tissue from 64 patients treated 4 weeks preoperatively with 20, 5, or 1 mg/d tamoxifen and 28 nontreated breast cancer controls were analyzed for coactivator and HER-2/neu mRNA expression using real-time reverse transcription-PCR. 20332317

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Using a panel of human breast cancer cells with different HER2 expression levels, these immunoliposomes decreased cancer cells viability in a dose-response manner and in correlation to their level of HER2 expression. 19896266

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Using a panel of human breast cancer cells with different HER2 expression levels, these immunoliposomes decreased cancer cells viability in a dose-response manner and in correlation to their level of HER2 expression. 19896266

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Surgical specimens from estrogen receptor-positive breast cancer and adjacent normal breast tissue from 64 patients treated 4 weeks preoperatively with 20, 5, or 1 mg/d tamoxifen and 28 nontreated breast cancer controls were analyzed for coactivator and HER-2/neu mRNA expression using real-time reverse transcription-PCR. 20332317

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Therapeutic CTD_human Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz[a]anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background. 18840765

2009

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz[a]anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background. 18840765

2009

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_human Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance. 19075277

2009