Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 29358691

2018

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT In conclusion, KCNQ1 and JMJD1C may prospectively contribute to the risk of T2D incidence among adults over the age of 40 and JMJD1C, but CDKAL1 may not, and iron status may interactively contribute to T2D incidence in women. 28406950

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT A total of 3 SNPs [rs9465871 (CDKAL1), rs10761745 (JMJD1C), and rs163177 (KCNQ1)] were selected as candidate SNPs related to T2D. 28406950

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. 27189021

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. 26818947

2016

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease. 25483131

2015

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395

2014

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. 23575436

2014

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Besides confirming seven established T2D loci (CDKAL1, CDKN2A/B, KCNQ1, CDC123, GLIS3, HNF1B, and DUSP9) at genome-wide significance, we identified two novel T2D loci, including G-protein-coupled receptor kinase 5 (GRK5) (rs10886471: P = 7.1 × 10(-9)) and RASGRP1 (rs7403531: P = 3.9 × 10(-9)), of which the association signal at GRK5 seems to be specific to East Asians. 22961080

2013

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455

2012

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827

2010

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. 19056611

2009

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. 19401414

2009

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900

2009

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. 18711366

2009

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. 18372903

2008

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. 17463246

2007

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. 17463248

2007

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT In addition to confirming two recently identified risk variants, we identified a variant in the CDKAL1 gene that was associated with T2D in individuals of European ancestry (allele-specific odds ratio (OR) = 1.20 (95% confidence interval, 1.13-1.27), P = 7.7 x 10(-9)) and individuals from Hong Kong of Han Chinese ancestry (OR = 1.25 (1.11-1.40), P = 0.00018). 17460697

2007

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 17554300

2007

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. 17460697

2007

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. 17463249

2007