Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT Hereditary non-polyposis colorectal cancer (HNPCC), predominantly due to germline MLH1/MSH2 mutations, is the commonest form of hereditary colorectal cancer (CRC), but data in Asians are sparse. 15996210

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT We sequenced the MLH1/MSH2 coding and promoter core regions in CRC patients diagnosed below age 40, and/or with multiple primary cancers or familial cancer clustering suggestive of HNPCC, and correlated deleterious mutations with clinical and tumour features. 15996210

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. 12792735

2004

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT These results indicate that there are different oncogenic pathways in the MSI sporadic colorectal cancers with germline missense mutations in the hMSH2 gene. 12792735

2004

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT To investigate the involvement of the mutated hMSH2 gene in carcinogenesis, we searched for alteration of the gene in 15 MSI tumors of Japanese patients with sporadic colorectal cancer by a polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) and DNA sequencing analyses. 12792735

2004

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma: detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases. 14504054

2004

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT The present study was designed to determine the frequency of germline mutations in the hMLH1 and hMSH2 genes in 31 families suspected of having hereditary nonpolyposis colorectal cancer who do not fulfill the criteria of the International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer but in whom a genetic basis for colon cancer is strongly suspected and 45 patients with sporadic early-onset colorectal cancer who developed colorectal cancer before the age of 40 years without any family history of colorectal cancer. 9559627

1998

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT Only one missense mutation of the hMSH2 gene was identified in 45 patients (2 percent) with sporadic early-onset colorectal cancer. 9559627

1998

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation UNIPROT Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer. 9559627

1998