|
rs6983267
|
|
Colorectal Carcinoma
|
G |
0.900 |
GeneticVariation
|
GWASDB |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
|
rs6983267
|
|
Colorectal Carcinoma
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers.
|
17618282 |
2007 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the population-based series, we also detected statistically significant associations between two SNPs on 8q24, rs10505477 and rs6983267, and risk of CRC (P = 0.005 and P = 0.002, respectively).
|
18056436 |
2007 |
|
rs10505477
|
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
Among 1,861 incident cases and 1,937 population-based controls matched on age, gender, ethnicity, and clinic, rs10505477 was associated with risk of CRC in a dominant model, with an odds ratio = 1.23, 95% confidence interval = 1.05-1.43, (p = 0.008).
|
17630503 |
2007 |
|
rs10505477
|
|
Colorectal Carcinoma
|
A |
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.
|
17618283 |
2007 |
|
rs10505477
|
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
GWASDB |
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
|
17618284 |
2007 |
|
rs10505477
|
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
In the population-based series, we also detected statistically significant associations between two SNPs on 8q24, rs10505477 and rs6983267, and risk of CRC (P = 0.005 and P = 0.002, respectively).
|
18056436 |
2007 |
|
rs10505477
|
|
Colorectal Carcinoma
|
A |
0.890 |
GeneticVariation
|
GWASDB |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.
|
17618283 |
2007 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
|
18372905 |
2008 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In contrast, the recently identified CRC susceptibility allele rs6983267 mapping to 8q24 was significantly associated with disease risk (P=8.94 x 10(-8)).
|
18362937 |
2008 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
As expected, a significant association between the G allele of rs6983267 and CRC [OR, 1.22; 95% confidence interval (CI), 1.08-1.38; P = 0.0018] was found, confirming the previous observations.
|
18172290 |
2008 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs6983267 locus is also strongly associated with colorectal cancer.
|
18704501 |
2008 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
|
18372905 |
2008 |
|
rs7014346
|
|
Colorectal Carcinoma
|
|
0.830 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs7014346
|
|
Colorectal Carcinoma
|
A |
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
18372901 |
2008 |
|
rs7014346
|
|
Colorectal Carcinoma
|
A |
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
18372901 |
2008 |
|
rs7837328
|
|
Colorectal Carcinoma
|
|
0.720 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs10808555
|
|
Colorectal Carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs6983267 in region 3, previously implicated in CRC risk, trended toward association with disease in European Americans but not in African Americans.
|
19520795 |
2009 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
|
19561607 |
2009 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The polymorphism rs6983267 showed a significant association with CRC in a Japanese population.
|
19857256 |
2009 |
|
rs6983267
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The element drove expression of a reporter gene in a pattern that is consistent with regulation by the key CRC pathway Wnt. rs6983267 affects a binding site for the Wnt-regulated transcription factor TCF4, with the risk allele G showing stronger binding in vitro and in vivo.
|
19561604 |
2009 |