Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. 17065690

2006

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism and its reported relationship to type 2 diabetes susceptibility and body mass accumulation prompted us to investigate the impact of this single nucleotide polymorphism (SNP) on antipsychotic-induced changes of body weight and body mass index (BMI) in a naturalistic study design. 22413765

2012

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance. 17408525

2007

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). 15715885

2005

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In a Mendelian randomization design, both HOMA-IR (instrumental variables: rs1801282, rs4607103) and βF (instrumental variable: rs4607103) were related to T2DM (p < 0.03-0.01 and p < 0.03, respectively). 23161442

2013

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Three-site haplotype analysis in the PPARG locus using the 2 marginally associated SNPs (P/rs11715073 and P/rs3892175) in combination with Pro12 Ala (P/rs1801282) revealed a strong association of 1 "risk" (CGC) (P = .003, permutation P = .015) and 1 "protective" (CAC) (P = .001, permutation P = .005) haplotype associated with T2D. 19846176

2010

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94). 18498634

2008

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our aim was to study the interaction effect between PPARγ gene (PPARG) polymorphisms Pro12Ala and 1431C>T and fat intake on incident T2D and BMI in a 9-year prospective cohort drawn from the French general population, the D.E.S.I.R. 21540831

2012

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes. 21968139

2011

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D. 25063576

2014

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Although our data indicate that the PPARG2 gene variants, independently, have no association with type 2 diabetes mellitus, the 2-loci genotype analysis involving -1279G/A and Pro12Ala variants and the 3-loci haplotype analysis have shown a significant association with type 2 diabetes mellitus in this South Indian population. 19846173

2010

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Pro12Ala mutation decreases PPARG activity and resistance to NIDDM. 22937051

2012

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D. 30064293

2018

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The Pro12Ala polymorphism (rs1801282), a nonsynonymous substitution of peroxisome proliferator-activated receptor-gamma (PPARG), has been robustly associated with type 2 diabetes. 19745552

2009

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE These results suggest that in the Taiwanese, the Pro12Ala PPARgamma2 gene variant may contribute to fat accumulation and a higher BMI independent of type 2 diabetes. 11079814

2000

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma 2 gene is suggested to associate with diabetic nephropathy and cardiovascular disease in type 2 diabetes. 18467141

2008

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE No effect of the Pro12Ala polymorphism on the rates of whole-body, skeletal muscle, or subcutaneous adipose tissue GU was observed in T2DM subjects. 19303976

2009

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism. 16050954

2005

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM. 25584717

2015

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The objective of the study was to test for an association between type 2 diabetes mellitus (T2DM) and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPAR-gamma) in families from Colorado. 17292728

2007

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Conflicting evidence exists as to whether the Pro12Ala single nucleotide polymorphism of the type 2 diabetes susceptibility gene peroxisome proliferator-activated receptor gamma (PPARG) also confers risk for type 1 diabetes (T1D). 18466209

2008

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The PPAR-gamma Pro12Ala gene polymorphism is associated with the response to pioglitazone in Chinese patients with type 2 diabetes mellitus. 20045142

2010

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis. 19766907

2009

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
G 0.900 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

dbSNP: rs1801282
rs1801282
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. 23386649

2013