|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
(1) To determine the allele and genotype frequency of the Pro12Ala PPARgamma2 amino acid variant in a Polish population; (2) To search for the association of the Pro12Ala polymorphism with T2DM in the examined population.
|
14581147 |
2003 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus.
|
12218380 |
2002 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid.
|
16920849 |
2006 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes.
|
12643137 |
2002 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A functional single nucleotide polymorphism (SNP) that predicts a proline to alanine substitution (Pro12Ala) within the coding region of this gene has previously been associated with obesity and type 2 diabetes in several populations.
|
12829658 |
2003 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the PPARG gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced fluid retention and edema in patients with type 2 diabetes.
|
16822823 |
2006 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
|
23559865 |
2013 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
|
30064293 |
2018 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although cross-sectional studies have associated the Pro12Ala polymorphism of PPARG with type 2 diabetes, prospective studies offer more opportunities to investigate genetic variants.
|
16567542 |
2006 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala.
|
20079163 |
2009 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although our data indicate that the PPARG2 gene variants, independently, have no association with type 2 diabetes mellitus, the 2-loci genotype analysis involving -1279G/A and Pro12Ala variants and the 3-loci haplotype analysis have shown a significant association with type 2 diabetes mellitus in this South Indian population.
|
19846173 |
2010 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the study was carried out on a sufficiently large sample, the conclusions do not support a major role for the Pro12Ala substitution of the PPAR-gamma gene in the etiology of type 2 diabetes.
|
10389855 |
1999 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism.
|
16050954 |
2005 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis.
|
11684868 |
2001 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among type 2 diabetes mellitus SNPs, rs1801282 is of particular interest because (i) it is harbored by peroxisome proliferator-activated receptor-γ2 (PPARγ2), which is the target for thiazolidinediones which are used as antidiabetic drugs, decreasing all-cause mortality in type 2 diabetes mellitus, and (ii) it is associated with insulin resistance and related traits, risk factors for overall mortality in type 2 diabetes mellitus.
|
26956846 |
2016 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.
|
14730381 |
2004 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
At present, adequate data is not available dealing with MTHFR (rs1801133) and PPARγ2 (rs1801282) gene polymorphisms and its association with type 2 diabetes mellitus cases among north Indian populations.
|
23036708 |
2012 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conflicting evidence exists as to whether the Pro12Ala single nucleotide polymorphism of the type 2 diabetes susceptibility gene peroxisome proliferator-activated receptor gamma (PPARG) also confers risk for type 1 diabetes (T1D).
|
18466209 |
2008 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes.
|
25974167 |
2015 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
|
17213274 |
2007 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes.
|
21833536 |
2011 |
|
rs1801282
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |