rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Arg16Gly genotype showed significant relationships to elevated central distribution of body fat and to systolic blood pressure, whilst the Glu27Glu genotype was associated with elevated leptin and triglyceride levels but not to other measurements, including obesity variables.
|
10971791 |
2000 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification.
|
15323067 |
2004 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
β2-adrenoceptor (β2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population.
|
20738880 |
2010 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Together, our findings suggest evidence for a two-locus interaction between the LEPR Gln223Arg and ADRB2 Arg16Gly variants in the risk of overweight/obesity, and highlight further the importance of multilocus effects in the genetic component of obesity.
|
21233811 |
2011 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95%CI [1.258-2.151]).
|
21483652 |
2011 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
|
21959333 |
2011 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors.
|
22094842 |
2011 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05).
|
22731644 |
2012 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, our results do not support an association between rs1042713 (Arg16Gly) polymorphisms and obesity in the populations investigated.
|
24960039 |
2014 |
rs1042713
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO<sub>2max</sub> , and ME.
|
28294290 |
2017 |