|
rs1001179
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Univariate analysis failed to demonstrate an association between either the -262C/T of the catalase gene promoter (rs1001179) or the C242T polymorphism of the P22phox gene (rs4673) or the 594C/T polymorphism of the glutathione peroxidase gene (rs1050450) and AH.
|
23701472 |
2014 |
|
rs10033464
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multiple clinical variables (including age, hypertension, lone AF) failed to significantly predict response to AADs; however, single nucleotide polymorphism (SNP) rs10033464 at 4q25 was an independent predictor of successful rhythm control in patients with typical AF carrying the ancestral allele (wild type) versus carriers of variant allele (odds ratio [OR]: 4.7, 95% confidence interval [CI]: 1.83 to 12, p = 0.0013.
|
22726630 |
2012 |
|
rs10046
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CYP19A1 rs10046 polymorphism is associated with cardiovascular risk factors such as circulating apoB, insulin resistance and hypertension in a sex- and obesity-specific manner.
|
26415088 |
2015 |
|
rs10050860
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multivariable Cox regression analysis showed an association of three tSNPs (<i>ERAP1</i>: rs469783 and rs10050860; <i>ERAP2</i>: rs2927615; all <i>p</i> < 0.05) with risk of incident hypertension.
|
29850473 |
2018 |
|
rs10086846
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension.
|
24015270 |
2013 |
|
rs10118757
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further, we also observed the combined effects of rs10118757 with alcohol drinking and hypertension, which increased the risk of ischemic stroke.
|
19427650 |
2009 |
|
rs1012657750
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with high Hcy and MTHFR 667CC, as well as those with low Hcy and 667CT+TT, showed lower odds of uncontrolled SBP (MTHFR 667CC+ high Hcy: OR: 0.338, 95% CI: 0.115-0.996, Pcombined = 0.049; MTHFR 667CT/TT+ low Hcy: OR: 0.421, 95% CI: 0.193-0.921, Pcombined = 0.030) compared to patients with low Hcy and MTHFR 667CC.<b>Conclusions</b>: Serum Hcy status and Hcy metabolism gene polymorphisms (MTHFR C667T and MTRR A66G) may have synergistic effects on the prevalence of HTN and dyslipidemia.
|
30786773 |
2020 |
|
rs1020608562
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS).
|
27118566 |
2016 |
|
rs10224002
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study demonstrated that SNPs rs10224002 may be associated with hypertension in the Chinese Han population and PRKAG2 may play a role in the etiology of hypertension and cardiovascular diseases.
|
30689184 |
2019 |
|
rs1037733674
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that the Gly40Ser polymorphism of the GCGR gene is associated with higher risk of hypertension and with enhanced proximal tubular sodium reabsorption, a factor possibly contributing to hypertension in this group.
|
11692154 |
2001 |
|
rs1040288
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results reveal a possible association between the rs11099680 RAAS polymorphism and uncontrolled AHT in MS-diagnosed patients. rs1040288 appears to be associated with uncontrolled blood pressure regardless of MS profile.
|
21471972 |
2011 |
|
rs1042039
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prior to Bonferroni correction, T allele frequency for rs206811 was significantly higher in patients with hypertension, as compared with the controls (64.1 vs. 59.4%; P=0.031); C allele frequency for rs1042039 was significantly higher in patients with hypertension, as compared with the controls (66.1 vs. 60.6%; P=0.011), C allele frequency for rs1054889 was significantly lower in patients with hypertension, as compared with the controls (38.8 vs. 44.8%; P=0.007); and A allele frequency for rs2073316 was significantly lower in patients with hypertension, as compared with the controls (29.2 vs. 34.4%; P=0.013).
|
26239312 |
2015 |
|
rs1042309696
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.
|
18212314 |
2008 |
|
rs1042522
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes.
|
27248495 |
2016 |
|
rs1043210477
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília.
|
21053180 |
2010 |
|
rs1043307
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
PSMD9 SNP rs74421874 [intervening sequence (IVS) 3 + nt460 G>A], rs3825172 (IVS3 + nt437 C>T) and rs1043307/rs2514259 (E197G A>G) are all linked to type 2 diabetes (T2D), maturity-onset-diabetes-of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular and T2D-microvascular disease, T2D-neuropathy, T2D-carpal tunnel syndrome, T2D-nephropathy, T2D-retinopathy, non-diabetic retinopathy and depression.
|
24648162 |
2014 |
|
rs1048101
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Some studies have found a positive correlation between the Arg347Cys polymorphism of the α1a-adrenergic receptor to hypertension and heart autonomic control.
|
24548768 |
2014 |
|
rs10489177
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10489177 GG genotype was associated with significantly increased risk for IS in individuals without hypertension (OR = 2.78, 95 % CI = 1.59-4.86) and in individuals without diabetes (OR = 1.93, 95 % CI = 1.27-2.94).
|
24122314 |
2014 |
|
rs104893831
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we describe an infant of Bangladesh ethnicity with a novel homozygous VHL(D126N) mutation with congenital polycythemia and dramatically elevated erythropoietin (EPO) levels, who developed severe fatal pulmonary hypertension.
|
24729484 |
2014 |
|
rs104893914
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between GR G678S gene polymorphisms and hypertension.
|
30545316 |
2018 |
|
rs104894145
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mutations Y329D and P428L retained a trace of activity, yet the two individuals with these mutations had severe hypertension and hypokalemia.
|
14715827 |
2004 |
|
rs10491093
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs (rs9899362, rs10491093, rs11658572 and rs9913883) were associated with the development of hypertension (P<0.05), but these associations require confirmation in future studies.
|
17728798 |
2008 |
|
rs10491334
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
|
26909912 |
2016 |
|
rs1049331
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, four meaningfully distinct clusters of patients were identified that were most strongly differentiated by their cardiovascular health status (histories of hypercholesterolemia and hypertension), and the alleles of ARMS2/HTRA1 rs1049331.
|
21682878 |
2011 |
|
rs1050606
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the luciferase experiment, ANXA5 rs1050606 had the most promoter activity in myocardial cells (P < .001).These results showed that ANXA5 rs1050606 was significantly associated with LVH in Chinese EH patients, likely via influencing ANXA5 expression in serum and in myocardial cells.
|
29095261 |
2017 |