rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found a significant contribution of the MTHFR 677C>T polymorphic variants to depression in postmenopausal women.
|
18801628 |
2008 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.
|
23900311 |
2013 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p = 0.7200), BMI (p = 0.1170), smoking habit (p = 0.4382), physical activity in daily life (p = 0.8492), scored cognitive function (p = 0.7229) or depression state (p = 0.8301).
|
23285094 |
2012 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
|
25012419 |
2014 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with late-onset depression had an increased rate of the C677T MTHFR gene mutation and other vascular risk factors.
|
11722155 |
2001 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.
|
19251870 |
2009 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.
|
26177556 |
2014 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Low folate is unlikely to be an important risk factor for depression during pregnancy and for postpartum depression, but may be a risk factor for depression outside of pregnancy, especially among women with the MTHFR C677T TT genotype.
|
21772318 |
2012 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T is associated with MA in individuals selected for depression study.
|
21635773 |
2011 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression.
|
21125200 |
2010 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
|
22668858 |
2012 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
|
24532086 |
2014 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Present meta-analysis supports that there is a meager significant association between MTHFR C677T polymorphism and depression risk.
|
28968218 |
2017 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of depression in the Chinese population (T vs. C: OR = 1.52, 95% CI = 1.24-1.85; TT + CT vs. CC: OR = 1.64, 95% CI = 1.16-2.30; TT vs. CC: OR = 2.19, 95% CI = 1.49-3.24; TT vs. CC + CT: OR = 1.80, 95% CI = 1.31-2.46).
|
26681493 |
2016 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.
|
17074966 |
2007 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
|
12796225 |
2003 |
rs1217691063
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
|
22739363 |
2012 |