|
rs2057482
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies.
|
31744467 |
2019 |
|
rs2057482
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, C1772T and G1790A but not rs2057482 were associated with increased risk for cancer.
|
24046090 |
2014 |
|
rs2057482
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results suggest that HIF1A rs2057482 polymorphism is involved in the risk of developing CAD and is associated with some metabolic parameters and cardiovascular risk factors.
|
24769354 |
2014 |
|
rs2057482
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, C1772T and G1790A but not rs2057482 were associated with increased risk for cancer.
|
24046090 |
2014 |
|
rs2057482
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genetic mutations within MAPK1 (rs6928, rs9340, rs11913721), HIF-1 (rs1087314, rs2057482), and HO-1 (rs2071746) could alter susceptibility to perimenopausal CAD in this Chinese population.
|
28444966 |
2017 |
|
rs2057482
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies.
|
31744467 |
2019 |
|
rs2057482
|
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study.
|
24769354 |
2014 |
|
rs2057482
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Taken together, this study provides additional evidence that genetic variation of the PECAM1 rs1867624 and HIF1A rs2057482 can mediate lipid levels in MI patients.
|
30678728 |
2019 |
|
rs2057482
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, significant protective effects on CRC outcomes conferred by adjuvant chemotherapy were exclusively observed in patients carrying CC genotype of rs2057482 and in those carrying AC/CC genotype of rs2301113.
|
24969897 |
2014 |
|
rs2057482
|
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Under a dominant model adjusted for age, visceral to subcutaneous adipose tissue (VAT/SAT) ratio, hypertension, type 2 diabetes mellitus (T2DM), HDL-C levels, hypercholesterolemia and hypertriglyceridemia, the rs2057482 T allele was associated with decreased risk of premature CAD when compared to healthy controls (OR = 0.616, P(dom) = 0.020).
|
24769354 |
2014 |
|
rs2057482
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the rs2057482-CC genotype increases the susceptibility to PDAC and associated with cancer progression.
|
26872370 |
2016 |
|
rs2057482
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
So that, our results provided the first insight into rs2057482 polymorphism of in the 3´-untranslated region of HIF-1α contributed to the risk of cervical cancer in a Chinese population and thus may serve as a reliable predictive factor of cervical cancer.
|
24195510 |
2014 |
|
rs2057482
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the combined variant genotypes of rs2057482 and rs11549467 were associated with increased PCa risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles).
|
23042446 |
2012 |
|
rs2057482
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs2057482
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the combined variant genotypes of rs2057482 and rs11549467 were associated with increased PCa risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles).
|
23042446 |
2012 |
|
rs2057482
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs2057482
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
So that, our results provided the first insight into rs2057482 polymorphism of in the 3´-untranslated region of HIF-1α contributed to the risk of cervical cancer in a Chinese population and thus may serve as a reliable predictive factor of cervical cancer.
|
24195510 |
2014 |
|
rs2057482
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, SNP rs2057482 in HIF1A gene is significantly associated with clinical outcomes of Chinese HCC patients after surgery, especially in those with aggressive status, which warrants further validation in other patient populations.
|
26115041 |
2015 |
|
rs2057482
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs2057482
|
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped four potentially functional single-nucleotide polymorphisms (rs779805 in VHL and rs11549465, rs11549467, and rs2057482 in HIF1A) and assessed their associations with RCC risk, clinicopathologic parameters in a case-control study of 620 patients and 623 controls, and the prognosis of RCC in a cohort of 311 patients.
|
21778301 |
2012 |
|
rs2057482
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
So that, our results provided the first insight into rs2057482 polymorphism of in the 3´-untranslated region of HIF-1α contributed to the risk of cervical cancer in a Chinese population and thus may serve as a reliable predictive factor of cervical cancer.
|
24195510 |
2014 |
|
rs2057482
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this analysis, the rs2057482 T allele was associated with decreased risk of obesity, central obesity, hypertension, hypercholesterolemia, hypertriglyceridemia and increased risk of T2DM.
|
24769354 |
2014 |
|
rs2057482
|
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this analysis, the rs2057482 T allele was associated with decreased risk of obesity, central obesity, hypertension, hypercholesterolemia, hypertriglyceridemia and increased risk of T2DM.
|
24769354 |
2014 |
|
rs2057482
|
|
Tumor Progression
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the rs2057482-CC genotype increases the susceptibility to PDAC and associated with cancer progression.
|
26872370 |
2016 |
|
rs7156573
|
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets.
|
22510845 |
2012 |