Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 21874001

2011

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs7903146 was genotyped in 1) a population-based sample of 587 twins (55-64 yr) with glucose tolerance ranging from normal to type 2 diabetes and 2) a population of 196 nondiabetic young (22-31 yr) and elderly (57-66 yr) twins. 18611970

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) have been shown to be predisposed to type 2 diabetes mellitus across many large studies. 21169132

2010

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=227), we genotyped rs7903146 and rs11196218 at TCF7L2, rs13266634 at SLC30A8, rs3811951 at PCSK1 and rs2021785 at PCSK2. 21437630

2012

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D. 30456822

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We report replication of association of four of the six SNPs with T2DM in this Khatri Sikh sample [rs7903146, (p = 0.010); rs11196205, (p = 0.011); rs10885409, (p = 0.002) and rs4918789, (p = 0.029)], under a dominant model conferring odds ratios (ORs) of 1.39, 1.44, 1.57 and 1.36, respectively. 18397358

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. 17460697

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Significant associations were found between type 2 diabetes and rs7903146, rs12255372, rs11196205, rs7901695, rs7895340 and rs4506565, with summary odds ratios (ORs) (95% confidence interval) of 1.39 (1.34-1.45), 1.33 (1.27-1.40), 1.20 (1.14-1.26), 1.32 (1.25-1.39), 1.21 (1.13-1.29) and 1.39 (1.29-1.49), respectively. 23188737

2013

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). 28254843

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM and suggest that TCF7L2 promotes pathological retinal neovascularization via ER stress-dependent upregulation of VEGFA. 23434931

2013

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results point to a protein complex binding across rs7903146 within TCF7L2 and suggests a possible mechanism by which this locus confers its T2D risk. 24667787

2015

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. 30814579

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The minor allele of each variant was significantly associated with type 2 diabetes; the greatest risk of developing the disease was conferred by rs7903146, with an allelic odds ratio (OR) of 1.31 (95% CI: 1.11 - 1.56, p = 1.96 x 10(-3)). 18291022

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE After adjusting for age, gender, drinking, smoking and body mass index (BMI), the association of <i>TCF7L2</i> rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined. 29100364

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. 19573884

2009

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASDB Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455

2012

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146</span>, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005). 31676834

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The results indicated that rs7903146C/T polymorphism was significantly associated with T2DM (T vs. C, OR = 1.73, 95% CI = 1.39-2.16). 23527206

2013

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed. 28101933

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The results show that rs7903146 of TCF7L2 gene is an important susceptibility gene for T2D mellitus in the province of Isfahan, Iran. 21678030

2012

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASDB A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. 17463248

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs7903146 variant of TCF7L2 significantly increased T2DM risk with an allelic odds ratio of 3.34 (95% CI [1.99-5.60], P < 0.0001). 19885641

2010

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We investigate the association between gene variant rs7903146 and metabolic parameters and examine in vitro and ex vivo gene expression of <i>TCF7L2</i> in human adipose tissue and progenitor cells from two independent populations of young healthy men with increased risk of type 2 diabetes due to low birth weight (LBW). 30721637

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASDB Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. 24390345

2014