rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively).
|
16936218 |
2006 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) and 1.60 (1.47-1.74) (P = 7.6 x 10(-28)), respectively.
|
17003360 |
2006 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) have been shown to predispose to type 2 diabetes mellitus across many large studies.
|
17020404 |
2006 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, case-control studies demonstrated that a TCF7L2 (transcription factor 7-like 2 gene) noncoding variant (rs7903146 T at-risk allele) was strongly associated with an increased risk of type 2 diabetes.
|
17065361 |
2006 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146.
|
17130514 |
2006 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Results of our analyses strongly confirmed the minor T alleles as risk variants for type 2 diabetes (rs7903146: OR (TvsC) [95% CI]=1.36 [1.18;1.58], p=0.00003, and rs12255372: OR (TvsG) [95% CI]=1.31 [1.13;1.51], p=0.0003).
|
17226113 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The consistent association between rs7903146 in TCF7L2 and type 2 diabetes in different ethnic groups, including the Japanese population, suggests that TCF7L2 is a common susceptibility gene for type 2 diabetes.
|
17245589 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A gene dosage effect of the rare allele of both variants was observed, the heterozygote CT group of rs7903146 having an odds ratio of 1.36 (95% CI 1.2-1.5, p=1.54 x 10(-7)) for type 2 diabetes and the TT homozygote having a greater risk (OR = 2.03, 95% CI 1.7-2.5, p=1.40 x 10(-12)).
|
17429603 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs7903146 shows similar trends, but its association with T2D is not as strong (OR = 1.39, p = 0.152).
|
17470138 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found 28 original published association studies dealing with the TCF7L2 rs7903146 polymorphism in T2D.
|
17476472 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The previously reported SNPs rs7903146 T- and rs12255372 T-alleles of the TCF7L2 gene were rare and were not associated with type 2 diabetes in a Chinese population, which may attribute to the low frequencies of these two SNPs.
|
17579206 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance.
|
17593304 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Rs11196205 was associated with T2D [odds ratio (OR) [95% confidence interval (CI)] = 2.11 (1.04-4.26)], whereas the association for rs7903146 [OR (95% CI) = 1.27 (0.71-2.29)] was not significant in the case-control sample.
|
17609304 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we analysed two single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, in the transcription factor 7-like 2 gene (TCF7L2), which are associated with an increased risk of type 2 diabetes mellitus.
|
17618413 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
|
17668382 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.900 |
GeneticVariation
|
GWASDB |
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
|
17668382 |
2007 |
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The CT/TT genotypes of SNP rs7903146 strongly predicted future T2D in 2 independent cohorts (Swedish and Finnish).
|
17671651 |
2007 |