Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively). 16936218

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) and 1.60 (1.47-1.74) (P = 7.6 x 10(-28)), respectively. 17003360

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) have been shown to predispose to type 2 diabetes mellitus across many large studies. 17020404

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, case-control studies demonstrated that a TCF7L2 (transcription factor 7-like 2 gene) noncoding variant (rs7903146 T at-risk allele) was strongly associated with an increased risk of type 2 diabetes. 17065361

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146. 17130514

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. 17460697

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 17463246

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASDB A genome-wide association study identifies novel risk loci for type 2 diabetes. 17293876

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT A genome-wide association study identifies novel risk loci for type 2 diabetes. 17293876

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASDB Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 17463246

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASCAT A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. 17460697

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. 17463248

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASDB A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. 17463248

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
A 0.900 GeneticVariation GWASDB Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. 17668382

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
A 0.900 GeneticVariation GWASCAT Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. 17668382

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Results of our analyses strongly confirmed the minor T alleles as risk variants for type 2 diabetes (rs7903146: OR (TvsC) [95% CI]=1.36 [1.18;1.58], p=0.00003, and rs12255372: OR (TvsG) [95% CI]=1.31 [1.13;1.51], p=0.0003). 17226113

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The consistent association between rs7903146 in TCF7L2 and type 2 diabetes in different ethnic groups, including the Japanese population, suggests that TCF7L2 is a common susceptibility gene for type 2 diabetes. 17245589

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE A gene dosage effect of the rare allele of both variants was observed, the heterozygote CT group of rs7903146 having an odds ratio of 1.36 (95% CI 1.2-1.5, p=1.54 x 10(-7)) for type 2 diabetes and the TT homozygote having a greater risk (OR = 2.03, 95% CI 1.7-2.5, p=1.40 x 10(-12)). 17429603

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The SNP rs7903146 shows similar trends, but its association with T2D is not as strong (OR = 1.39, p = 0.152). 17470138

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We found 28 original published association studies dealing with the TCF7L2 rs7903146 polymorphism in T2D. 17476472

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The previously reported SNPs rs7903146 T- and rs12255372 T-alleles of the TCF7L2 gene were rare and were not associated with type 2 diabetes in a Chinese population, which may attribute to the low frequencies of these two SNPs. 17579206

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance. 17593304

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Rs11196205 was associated with T2D [odds ratio (OR) [95% confidence interval (CI)] = 2.11 (1.04-4.26)], whereas the association for rs7903146 [OR (95% CI) = 1.27 (0.71-2.29)] was not significant in the case-control sample. 17609304

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we analysed two single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, in the transcription factor 7-like 2 gene (TCF7L2), which are associated with an increased risk of type 2 diabetes mellitus. 17618413

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The CT/TT genotypes of SNP rs7903146 strongly predicted future T2D in 2 independent cohorts (Swedish and Finnish). 17671651

2007