rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was a tendency towards significantly increased risk for SNPs rs1447295 and rs6983267 in men with early-onset prostate cancer.
|
21557270 |
2011 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The highest significance in Caucasian men was found for rs6983267; the AA genotype reduced the risk for PCa [odds ratio (OR) = 0.48, 95% confidence interval (CI) = 0.35-0.65, P = 2.74 x 10(-6)].
|
19528667 |
2009 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
These included correlations between an intergenic CpG site at Chr8:128393157 and the prostate cancer SNP rs16902094 (ρ = -0.54; P = 9.7 × 10(-7); q = 0.002), a PRNCR1 CpG site at Chr8:128167809 and the prostate cancer SNP rs1456315 (ρ = 0.52; P = 1.4 × 10(-6); q = 0.002), and two POU5F1B CpG sites and several prostate/colorectal cancer SNPs (for Chr8:128498051 and rs6983267, ρ = 0.46; P = 2.0 × 10(-5); q = 0.01).
|
25315430 |
2014 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, though no association was observed between the rs</span>6983267 polymorphism and risk of prostate cancer, subgroup analysis according to ethnicity showed a significant association between the rs6983267 polymorphism and risk of prostate cancer among white European men [recessive model: GG vs TG + TT, OR=1.21, (95% CI: 1.03, 1.42), P=0.02].
|
27009866 |
2016 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer.
|
19895682 |
2009 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory.
|
26159557 |
2015 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.
|
18231127 |
2008 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Significant associations were observed for rs4430796 TT with Gleason scores of ≥ 7 (OR = 1.76, 95% CI = 1.14-2.73) and prostate-specific antigen (PSA) levels of ≥ 10 ng/ml at diagnosis (OR = 1.63, 95% CI = 1.01-2.63), as well as for rs6983267 GG with stage 3-4 CaPs (OR = 1.91, 95% CI = 1.01-3.61).
|
22561070 |
2013 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78).
|
17401363 |
2007 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The results of the meta-analyses indicate that rs6983267, rs1447295, rs6983561, rs7837688, rs16901979, and DG8S737 are significantly associated with a higher risk for PCa for at least one race, whereas the variants rs13254738 and rs7000448 are not.
|
22382457 |
2012 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The polymorphism rs6983267 from region 3 of the chromosome 8q24 appears to be a prominent risk factor for PCa and a biomarker for cancer aggressiveness in the group of patients who presented higher levels of PSA at the time of diagnosis.
|
24224612 |
2014 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Analysis of the National Cancer Institute's Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer association study database alone and in combination with our data provided further evidence for this second prostate cancer risk locus; in the combined analysis, the allele frequencies for rs6983267 differed statistically significantly between case patients and control subjects (P = 1.61 x 10(-9)).
|
17925536 |
2007 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.
|
18768513 |
2008 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker.
|
19047180 |
2008 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association.
|
18360876 |
2008 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
A highly significant association (odds ratio=2.84 and p-value=0.002) was found between rs6983267 and prostate cancer in the Greek population.
|
22070222 |
2011 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Similarly, in a subgroup analysis of European and Asian descent, our results revealed that there are associations between rs6983267 T/G polymorphism and PCa susceptibility with the dominant model (GG vs GT+TT), recessive model (GG+GT vs TT), and homozygote comparison (GG vs TT).
|
26782586 |
2015 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Correlation between genotypes and biopsy outcome (positive or negative) and Gleason score (≤6 or >6) were studied by univariate and multivariable analysis. rs1447295 and rs6983267 risk variants were found to be associated with the presence of PCa in univariate analysis. rs6983267 genotype remained significantly linked to a positive biopsy (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.06-2.59, P = 0.026) in multivariable analysis, but rs1447295 genotype did not (OR = 1.47, 95% CI: 0.89-2.43, P = 0.13).When biopsy outcome was stratified according to Gleason score, risk variants of rs1447295 were associated with aggressive disease (Gleason score ≥7) in univariate and multivariable analysis (OR = 2.05 95% CI: 1.10-3.79, P = 0.023). rs6983267 GG genotype was not related to aggressiveness.
|
21308149 |
2011 |
rs6983267
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21).
|
18726982 |
2008 |