|
rs401681
|
|
melanoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Also, the SNP rs401681 in the TERT-CLPTM1L locus was replicated for the association with melanoma risk.
|
21116649 |
2011 |
|
rs401681
|
|
melanoma
|
A |
0.860 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
|
rs401681
|
|
melanoma
|
A |
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
|
rs401681
|
|
melanoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
In the melanoma dataset, two pancreatic cancer susceptibility variants were associated: NR5A2 (rs12029406; OR, 1.39; 95% CI, 1.01-1.92; P = 0.04) and CLPTM1L-TERT (rs401681; OR, 1.16; 95% CI, 1.01-1.34; P = 0.04).
|
24642353 |
2014 |
|
rs401681
|
|
melanoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
In a multivariable model that included only the most statistically significant findings from univariable modeling and adjusted for pigmentary phenotype, back nevi, and baseline features, we found TERT/CLPTM1L rs401681 (P = 0.004), TYRP1 rs2733832 (P = 0.006), MTAP rs1335510 (P = 0.0005), TYR rs10830253 (P = 0.003), and MX2 rs45430 (P = 0.008) to be significantly associated with multiple primary melanoma, while NCOA6 rs4911442 approached significance (P = 0.06).
|
25837821 |
2015 |
|
rs401681
|
|
melanoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
rs401681
|
|
melanoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
We evaluated the association between single nucleotide polymorphism (SNP) rs401681 (C > T) and mean telomere length, using quantitative real-time PCR, in blood-extracted DNA collected from 11,314 cancer-free participants from the Sisters in Breast Screening study, the Melanoma and Pigmented Lesions Evaluative Study melanoma family study, and the SEARCH Breast, Colorectal, Melanoma studies.
|
20570912 |
2010 |
|
rs401681
|
|
melanoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
We also obtained significant results when we tested the association between rs401681 variant (TERT-CLPTM1L locus) with melanoma risk (Odds ratio, OR; 95% confidence interval, CI=1.24 (1.08-1.43); p-value, 3×10(-3)).
|
25457634 |
2014 |
|
rs45430
|
|
melanoma
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
|
rs45430
|
|
melanoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
In a multivariable model that included only the most statistically significant findings from univariable modeling and adjusted for pigmentary phenotype, back nevi, and baseline features, we found TERT/CLPTM1L rs401681 (P = 0.004), TYRP1 rs2733832 (P = 0.006), MTAP rs1335510 (P = 0.0005), TYR rs10830253 (P = 0.003), and MX2 rs45430 (P = 0.008) to be significantly associated with multiple primary melanoma, while NCOA6 rs4911442 approached significance (P = 0.06).
|
25837821 |
2015 |
|
rs45430
|
|
melanoma
|
T |
0.820 |
GeneticVariation
|
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |
|
rs45430
|
|
melanoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), rs45430, in an intron of the MX2 gene, was previously reported as a novel melanoma susceptibility locus in genome-wide association studies.
|
31660681 |
2019 |
|
rs45430
|
|
melanoma
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
|
rs3219090
|
|
melanoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)).
|
21983785 |
2011 |
|
rs3219090
|
|
melanoma
|
C |
0.820 |
GeneticVariation
|
GWASDB |
We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)).
|
21983785 |
2011 |
|
rs3219090
|
|
melanoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
We confirmed the proposed role of rs3219090, located on the PARP1 gene, and rs12203592, located on the IRF4 gene, as protective to MM along the same lines as have previous genome-wide associated works.
|
23537197 |
2013 |
|
rs3219090
|
|
melanoma
|
C |
0.820 |
GeneticVariation
|
GWASCAT |
We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)).
|
21983785 |
2011 |
|
rs910873
|
|
melanoma
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |
|
rs910873
|
|
melanoma
|
T |
0.810 |
GeneticVariation
|
GWASCAT |
Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)).
|
18488026 |
2008 |
|
rs910873
|
|
melanoma
|
T |
0.810 |
GeneticVariation
|
GWASDB |
Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)).
|
18488026 |
2008 |
|
rs910873
|
|
melanoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
Our results do not support an association between CMM and any of the STX17 SNPs and provide no evidence for interactions between the melanoma risk SNP rs910873 on chromosome 20 and any of the STX17 SNPs.
|
19209086 |
2009 |
|
rs7023329
|
|
melanoma
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies three loci associated with melanoma risk.
|
19578364 |
2009 |
|
rs7023329
|
|
melanoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
One SNP in MTAP (methylthioadenosine phosphorylase) (rs7023329) that was previously associated with melanoma and nevi in multiple genome-wide association studies was associated with CRC, CA and OS by ASSET (P=0.007).
|
23361049 |
2013 |
|
rs7023329
|
|
melanoma
|
|
0.810 |
GeneticVariation
|
GWASDB |
A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q.
|
21706340 |
2012 |
|
rs7023329
|
|
melanoma
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |