|
rs6547741
|
|
Malignant neoplasm of mouth
|
|
0.710 |
GeneticVariation
|
BEFREE |
Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L).
|
27749845 |
2016 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Subgroup analysis by ethnicity suggested that there was an obvious association between XRCC1 Arg194Trp polymorphism and ora</span>l cancer</span> risk in Asians under three genetic models.
|
23681796 |
2013 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Subgroup analyses according to ethnicity, tumor site, publication year, genotyping method also detected no significant association in any subgroup, except that oral cancer was associated with Arg194Trp variant in recessive model.
|
24086310 |
2013 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Similarly, the pseudo-haplotype of rs2040639-rs861539-rs2075685 (XRCC2-XRCC3-XRCC4) and rs2040639-rs861539-rs2075685-rs1799782 (XRCCs 1-4) with specific genotype pattern (AG-CC-TG and CT-AG-CC-TG) among three and four combinational SNPs were significantly associated with oral cancer.
|
18410587 |
2008 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
The best two-factor based G×G interaction of ora</span>l cancer included the XRCC1 rs1799782 and XRCC2 rs2040639 [OR=3.13, 95% CI=1.66-6.13].
|
25831063 |
2015 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer.
|
22775506 |
2013 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
rs1799782
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, after stratification, significant association was found between the XRCC1 Arg194Trp polymorphism and oral cancer risk among Asians, showing an OR of 1.347 (95% confidence interval (CI): 1.000, 1.814) for allele comparison, 1.378 (95% CI: 1.070, 1.775) for TT homozygotes versus CC homozygotes, and 1.420 (95% CI: 1.041, 1.936) for comparison under the dominant model.
|
19713684 |
2009 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico.
|
11925474 |
2002 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Pooled results indicated that neither C677T</span> nor A1298C polymorphism was associated with oral cancer susceptibility.
|
28138253 |
2017 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
The goals of this study were to evaluate the association of three genotypic polymorphism (MTHFR C677T, MTHFR A1298C and CBS 844ins68) and oral cancer risk in southeastern Brazilians and evaluate the interactions between polymorphisms and clinical histopathological parameters.
|
26749456 |
2016 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Here we observed MTHFR C677T to influence oral cancer susceptibility, while A1298C polymorphism associated with patient prognosis.
|
20923444 |
2011 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Those patients with MTHFR C677T CT and TT genotypes also had a lower risk of oral cancer metastasis.
|
21737671 |
2011 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes.
|
20940365 |
2011 |
|
rs1217691063
|
|
Malignant neoplasm of mouth
|
|
0.080 |
GeneticVariation
|
BEFREE |
These results suggest that MTHFR C677T polymorphism may play a role in oral cancer carcinogenesis in Asian population and heavy drinkers.
|
24488626 |
2014 |
|
rs878854066
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigated joint effects of seven putatively functional polymorphisms of p53 (codon 72 Arg/Pro), p73 (4/14 GC/AT), murine double minute 2 gene (MDM2; A2164G and T2580G) and MDM4 (rs11801299 G > A, rs10900598 G > T and rs1380576 C > G) on risk of human papillomavirus (HPV)16-associated oral cancer in a case-control study with 325 cases and 335 cancer-free controls.
|
22052649 |
2012 |
|
rs878854066
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
p53 polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer development in Gujarat, West Indian population.
|
23621193 |
2013 |
|
rs878854066
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India.
|
14577584 |
2003 |
|
rs878854066
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present meta-analysis of currently available data shows no association between the p53 codon 72 Arg/Pro polymorphism and oral cancer risk.
|
23192640 |
2013 |
|
rs878854066
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
In the current meta-analysis which used the quantitative data synthesis for the first time, our study demonstrated that p53 Arg72Pro polymorphism together with HPV infection might jointly alter an individual's susceptibility to the risk of oral cancer.
|
26123760 |
2015 |
|
rs397507444
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
The MTHFR C677T genotype, but not the A1298C, was differently distributed between the oral cancer and control groups.
|
21737671 |
2011 |
|
rs397507444
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here we observed MTHFR C677T to influence oral cancer susceptibility, while A1298C polymorphism associated with patient prognosis.
|
20923444 |
2011 |
|
rs397507444
|
|
Malignant neoplasm of mouth
|
|
0.050 |
GeneticVariation
|
BEFREE |
The goals of this study were to evaluate the association of three genotypic polymorphism (MTHFR C677T, MTHFR A1298C and CBS 844ins68) and oral cancer risk in southeastern Brazilians and evaluate the interactions between polymorphisms and clinical histopathological parameters.
|
26749456 |
2016 |