rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics.
|
16969277 |
2006 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism.
|
21231925 |
2011 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
|
16476412 |
2006 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.
|
16936704 |
2006 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025).
|
17640440 |
2007 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated.
|
21947654 |
2011 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions.
|
27052366 |
2016 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis.
|
18407467 |
2008 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistically significant results were found in meta-analysis but one study reported that the rs4680 Val allele was associated with AD-related psychosis.
|
22483294 |
2012 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.
|
29444152 |
2018 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis.
|
30084963 |
2019 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.
|
21073668 |
2011 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated.
|
28142064 |
2017 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The individual SNP analysis confirmed an association for the valine/methionine variant with AD-P. Haplotype analyses revealed that the alleles at four loci (rs737865, rs737864, intron 1 C2754delC, rs4680) interacted to create the risk of psychosis in AD, as A-C-C-G haplotype (OR=2.08, 95% CI=1.02-4.27, P=0.044) and G-C-delC-G haplotype (OR=2.54, 95% CI=1.32-4.90, P=0.006) in respect to the most common and not-at-risk A-C-C-A haplotype which was significantly overrepresented in AD-P.
|
16837108 |
2007 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms.
|
17525974 |
2008 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the phenotypic expression of first episode psychosis at onset.
|
18092319 |
2008 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val homozygotes) on test performance before and after antipsychotic treatment in 32 first episode psychosis (FEP) patients was examined.
|
29941295 |
2018 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene influences prefrontal cognitive function and increases the risk for schizophrenia.
|
15169701 |
2004 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both neuropsychological performance and brain structure in patients with psychosis, in their relatives and in healthy individuals (step 1).
|
23527885 |
2013 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were analyzed in a sample of 84 adolescent Caucasian patients with first-episode psychosis (ages 11-17) and 85 healthy Caucasian controls (ages 10-17).
|
18351593 |
2008 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on MTHFR C677T genotype.
|
22128864 |
2012 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis.
|
28635556 |
2017 |
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis.
|
20493536 |
2010 |